Date of download: 5/31/2016 From: The Pathogenesis of Mucosal Inflammation in Murine Models of Inflammatory Bowel Disease and Crohn Disease Ann Intern.

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Volume 17, Issue 5, Pages (November 2002)
Nod2 in Normal and Abnormal Intestinal Immune Function
John T. Chang, William J. Sandborn  Gastroenterology 
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Date of download: 5/31/2016 From: The Pathogenesis of Mucosal Inflammation in Murine Models of Inflammatory Bowel Disease and Crohn Disease Ann Intern Med. 1998;128(10): doi: / Top and bottom left.Top and Bottom right.[2]Secretion of interferon-γ and interleukin-5 by purified CD4+ T cells. Cells were obtained from the lamina propria of six controls (black bars), eight patients with Crohn disease (striped bars), and six patients with ulcerative colitis (white bars). These cells were stimulated by anti-CD3 and anti-CD2 (alone or in combination with anti-CD28) and were enumerated by enzyme-linked immunospot assay (ELISPOT) analysis as described elsewhere. Error bars represent the mean ± SE from six experiments. Unstim = unstimulated cells. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 5/31/2016 From: The Pathogenesis of Mucosal Inflammation in Murine Models of Inflammatory Bowel Disease and Crohn Disease Ann Intern Med. 1998;128(10): doi: / Mechanism of colitis induction and tolerance in trinitro-benzene sulfonic acid (TNBS) colitis.Intrarectal administration of TNBS and formation of trinitrophenyl-haptenated colonic protein lead to induction of a polarized Th1 T-cell response in the lamina propria that is not counter-regulated by transforming growth factor-β (TGF-β)-producing T cells; the resultant unfettered interferon-γ production leads to activation of macrophages, production of inflammatory cytokines, and development of colitis. Oral administration of trinitrophenyl-haptenated colonic protein leads to induction of T cells producing TGF-β, which shuts down the excessive Th1 T-cell response of TNBS colitis. APC = antigen-presenting cell; TNF-α = tumor necrosis factor-α; PP = Peyer patch; T = T cell. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 5/31/2016 From: The Pathogenesis of Mucosal Inflammation in Murine Models of Inflammatory Bowel Disease and Crohn Disease Ann Intern Med. 1998;128(10): doi: / Mechanism of colitis induction in the interleukin-2 knockout mouse.Interleukin-2 deficiency leads to an excessive Th1 T-cell response in the lamina propria because of a defect in the ability to generate a Th2 T-cell response and T cells producing transforming growth factor-β (TGF-β). This problem is compounded by the formation of autoreactive Th1 T cells in the thymus that migrate to the colon. APC = antigen-presenting cell; MAC = macrophage; TNF-α = tumor necrosis factor-α. The minus sign indicates a negative suppressor effect. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

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