CoRPS Center of Research on Psychology in Somatic diseases Poor health status in implantable cardioverter defibrillator patients: Shock, patient pre implantation.

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Presentation transcript:

CoRPS Center of Research on Psychology in Somatic diseases Poor health status in implantable cardioverter defibrillator patients: Shock, patient pre implantation personality, or both as culprits? Susanne S. Pedersen, Professor of Cardiac Psychology

CoRPS Declaration of interest Moderate consultancy and speaker’s fees from: Cameron Health BV Medtronic Sanofi-Aventis St. Jude Medical

CoRPS Affiliations Prof.dr. Susanne S. Pedersen CoRPS - Center of Research on Psychology in Somatic diseases, Tilburg University, The Netherlands Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands Department of Cardiology, Odense University Hospital, Denmark Phone: + 31 (0)

CoRPS ICD shock: A critical event to patients Ahmad et al. PACE 2000;23:931-3 Sears et al. Pacing Clinical Electrophysiol 2010; 33: Used as primary and secondary prevention of sudden cardiac death ICD is superior to anti-arrhythmic drugs in saving lives The ICD can shock with up to volts “It’s like getting kicked in the chest by a big horse!” Implantable cardioverter defibrillator (ICD)

CoRPS Intra-individual changes in psychological functioning between pre implantation and 12 months stratified by ICD shock* * A positive mean score change indicates improvement in psychological functioning Explained variance in changes: ICD concerns: 5.1% Anxiety: 3.1% Depression: 3.5% Pedersen, Jordaens & Theuns. Int J Cardiol 2011;In Press N = 308

CoRPS Sears et al. Psychosomatics 2005;46:451-7 Predictors of quality of life (8 months) * Social support, optimism, depression, anxiety Age, LVEFPsychological variables* ShocksTotal variance General health 21.2%39.9%3.5%64.5% Mental health13.7%27.4%0.7%41.8% Physical health 23.4%24.1%7.3%54.8% N = 88

CoRPS Prevalence of anxiety and depression in patients stratified by Type D and shocks Pedersen, Jordaens, Theuns et al. Psychosom Med 2004;66:714-9 % N = 182

CoRPS 8 Predictors of persistent depression Pedersen, Jordaens,Theuns et al. Am J Cardiol 2011;108:69-74 HR: 2.60 [95% CI: ] HR: 8.30 [95% CI: ] HR: 2.09 [95% CI: ] HR: 1.92 [95% CI: ] HR: 2.47 [95% CI: ] HR: 2.29 [95% CI: ] N = 386

CoRPS Pedersen et al. Pacing Clin Electrophysiol 2010;33: Given that programming of the ICD is changing, leading to fewer shocks and improved quality of life, it may be timely to also examine the influence of other determinants (e.g. heart failure progression and personality) of patient-reported outcomes... Shock viewpoint

CoRPS Study objective To compare the influence of shock and the patient’s pre implantation personality on health status, using a prospective study design

CoRPS Methods: Participants Consecutive patients (N=383; 79% men; mean age = 57.7 ± 12.0) with a first-time ICD or CRT-D Implanted between August 2003 to March 2010 in the Erasmus Medical Center, Rotterdam Participating in Mood and personality as precipitants of arrhythmia in patients with an Implantable cardioverter Defibrillator: A prospective Study (MIDAS)

CoRPS Methods: Design and measures Prospective 12-months follow-up study Demographic and clinical characteristics (incl. device therapy) obtained from medical chart abstraction and purpose-designed questions Patients completed: o Type D Scale (DS14) at baseline – Type D personality o Short Form Health Survey (SF) 36 at baseline, 3-, 6-, and 12 months post implant – Health status Statistical analysis: Generalized linear mixed modeling

CoRPS Results 23.5% had a Type D personality 13.8% experienced a shock during the 12-month follow-up period o 10.7% an appropriate shock o 3.9% an inappropriate shock Analyses: any shock

CoRPS Health status stratified by shock

CoRPS Health status stratified by Type D

CoRPS Health status stratified by Type D and shock

CoRPS Independent predictors of health status at 12 months* Shock during FUType D personality Physical functioningns-4.42 (-8.65 – -0.19) Role functioning - physical ( – -3.82)-8.02 ( – -0.54) Bodily painns-4.04 (-8.04 – -0.04) Social functioning-6.74 ( – -1.42)-6.21 ( – -2.01) Mental health-5.27 (-8.84 – -1.71)-3.10 (-6.02 – -0.35) Role functioning – emotionalns-6.75 ( – -.35) Vitality-4.79 (-9.02 – -0.54)ns General health perceptionsns * Adjusted for gender, age, marital status, education, ICD indication, CRT, CAD, atrial fibrillation, diabetes, smoking, amiodarone, beta-blockers, psychotropic medication, and baseline health status Shock: 4/8 domains – ↓ 4.79 to points Type D personality: 6/8 domains – ↓ 3.10 to 8.02

CoRPS Take home message ICD shock (4/8 sub domains) and Type D personality (6/8 sub domains) were independent predictors of poor health status Given reduction in incidence of shocks, time to expand our focus to other factors in clinical practice to identify patients at risk of poor health status and well being

CoRPS Acknowledgements FUNDING VENI ( ) from the Netherlands Organisation for Scientific Research (NWO) VIDI grant ( ) from the Netherlands Organisation for Health Research and Development (ZonMw) CO-AUTHORS Fetene B Tekle (PhD) – Department of Methodology and Statistics, Tilburg University, NL Madelein T Hoogwegt (MSc) – Department of Medical Psychology, Tilburg University, NL Luc Jordaens (MD, PhD) – Department of Cardiology, Thoraxcenter, Erasmus Medical Center, NL Dominic AMJ Theuns (PhD) - Department of Cardiology, Thoraxcenter, Erasmus Medical Center, NL