What is going on between defibrotide and endothelial cells? Snapshots reveal the hot spots of their romance by Marta Palomo, Enrique Mir, Montse Rovira,

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Presentation transcript:

What is going on between defibrotide and endothelial cells? Snapshots reveal the hot spots of their romance by Marta Palomo, Enrique Mir, Montse Rovira, Ginés Escolar, Enric Carreras, and Maribel Diaz-Ricart Blood Volume 127(13): March 31, 2016 ©2016 by American Society of Hematology

Uptake of defibrotide by endothelial cells. Marta Palomo et al. Blood 2016;127: ©2016 by American Society of Hematology

DF internalization by SK cells. Marta Palomo et al. Blood 2016;127: ©2016 by American Society of Hematology

Specificity of DF labeling and DF interaction with ECs. (A) Confocal microscopy images show no green staining when SK cells (red staining with wheat germ agglutinin for membranes) were incubated only with Alexa 488 compared with (B) the incubation of SK cel... Marta Palomo et al. Blood 2016;127: ©2016 by American Society of Hematology

DF is internalized by ECs through macropinocytic mechanisms. Marta Palomo et al. Blood 2016;127: ©2016 by American Society of Hematology

Inflammation of ECs is prevented by DF interaction with the cell membrane. Marta Palomo et al. Blood 2016;127: ©2016 by American Society of Hematology

The antioxidant effect of DF on ECs is caused by its interaction with the cell membrane. Marta Palomo et al. Blood 2016;127: ©2016 by American Society of Hematology