Glycolysis during rest and exercise. Fates of Pyruvate Conversion to acetyl-CoA (oxidative phosphorylation) Lactate (glycolysis) AAT - increases TCA intermediates.

Slides:



Advertisements
Similar presentations
Glycolysis: The Central Pathway of Glucose Degradation NUTR 543 Advanced Nutritional Biochemistry Dr. David L. Gee Central Washington University.
Advertisements

Glycolysis Glucose utilization in cells of higher plants and animals.
Introduction of Glucose Metabolism
Three Fates of Pyruvate Pyruvate  acetyl-CoA Occurs in mitochondria Produce CO 2 and NADH + H + Pyruvate Dehydrogenase Aerobic **Acetyl-CoA used in the.
Pyruvate and Energetics of Glycolysis C483 Spring 2013.
Energy Production conversion of chemical energy to mechanical energy stored in the form of ATP breakdown of ATP releases energy and produces heat –used.
Gluconeogenesis : An overview
Overview of catabolic pathways
Chapter 9 (continued) Fermentation. glucose 2 ATP 2 NADH 2 pyruvate 2 ATP 8 NADH 2FADH 2 O ATP water glycolysis citric Acid cycle oxidative phosphorylation.
KREBS CYCLE. Introduction Let us review fates of Pyruvate Depending on the oxidation state of the cell: Aerobic – converted to acetyl-CoA via TCA cycle.
Aulani "Biokimia" Presentation4 Aulanni’am Biochemistry Laboratory Chemistry Departement Brawijaya University Carbohydrate Metabolism Cont….
GlycolysisGluconeogenesis. Glycolysis - Overview One of best characterized pathways Characterized in the first half of 20th century Glucose --> 2 pyruvates.
A.Coupled reactions The additivity of free energy changes allows an endergonic reaction to be driven by an exergonic reaction under the proper conditions.
Prentice Hall c2002Chapter 121 Chapter 12 - The Citric Acid Cycle The citric acid cycle is involved in the aerobic catabolism of carbohydrates, lipids.
Fig 10.5 Overview of catabolic pathways Prentice Hall c2002 Chapter 11.
Enzyme Nomanclature.
Total Energy per glucose A) Cytosol – Glycolysis 2 NADH 2 ATP B) Mitochondrion – Pyruvate dehydrogenase 2 NADH --Krebs 6 NADH 2 FADH 2 2 GTP 1.
Metabolic Pathways Most of the ATP that is generated in the body is produced through the process of oxidative phosphorylation. This process is dependent.
Metabolism Basics Title - metabolism basics.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 6.9 Scheme of Metabolism Slide number 1 CO 2 GLUCOSE (f) Fermentation.
Glycolysis Biochemistry, 4 th edition, RH Garrett & CM Grisham, Brooks/Cole (Cengage); Boston, MA: 2010 pp Instructor: Kirill Popov.
CHAPTER 16 Glycolysis.
Aerobic Metabolism. Summary of Anaerobic Glycolysis Glucose + 2 ADP + 2 P i 2 Lactate + 2 ATP + 2 H 2 O + 2 H +
Oxidative Decarboxylation and Krebs Cycle By Reem M. Sallam, M.D.; Ph.D. Clinical Biochemistry Unit, Pathology Dept. College of Medicine, King Saud University.
Glycolysis and Gluconeogenesis Dr M. D. Lloyd 5W 2.13;
Chapter 13 - The Citric Acid Cycle The citric acid cycle is involved in the aerobic catabolism of carbohydrates, lipids and amino acids Intermediates of.
Carbohydrate anabolism We have covered some aspects of carbohydrate catabolism: glycolysis, PPP, citric acid cycle, etc. and now we turn to carbohydrate.
FERMENTATION: Anaerobic Glycolysis. CATABOLIC FATES OF PYRUVATE.
Glycolysis 1. From glucose to pyruvate; step reactions; 3
Citric acid cycle Krebs cycle, tricarboxylic acid cycle TCA The central function is the oxidation of acetyl CoA to CO2 - It is the final common pathway.
TCA: Tricarboxylic Acid cycle Also known as: Krebs cycle & The Citric Acid Cycle.
Why Lactate is a Friend to Exercise. 1 st : Lactate & H+ temporal relationship b/w  in force & H+ accumulation at same time, metabolic products  : ADP,
Cell Respiration II: Fermentation reactions During strenuous exercise or when O2 is unavailable or low in the environment, ATP production still needs to.
Glycolysis Rate Limiters  LDH  Hexokinase  PFK-1  NADH/NAD + ratio  PHOS  Ca 2+  Epinephrine.
ll2011/stryer7/16/figure_16_16.jpg.
How is the oxidation of pyruvate regulated? PDH complex is regulated by product inhibition and covalent modification Product inhibition: –Acetyl-CoA.
Citric Acid Cycle. Figure 17-2 Citric Acid Cycle.
1 SURVEY OF BIOCHEMISTRY More on Glycogen Control Citric Acid Cycle.
Oxidative Decarboxylation of Pyruvate
Gluconeogenesis Title - making glucose.
Glycolysis Glucose → pyruvate (+ ATP, NADH) Preparatory phase + Payoff phase Enzymes –Highly regulated (eg. PFK-1 inhibited by ATP) –Form multi-enzyme.
The sweet side of catabolism: carbohydrates as cellular fuels Russian National Research Medical University Maxim A. Abakumov Moscow, 2014.
Glycolysis Regualtion
Cell Respiration Chapter 9. Slide 2 of 40 Cellular Respiration.
Chapter 16, Stryer Short Course
Glycolysis Under Anaerobic Conditions
Harvesting energy Genes and Development Biology 122.
Glycolysis Eric Niederhoffer SIU-SOM Glucose Pyruvate Lactate 10 steps No O 2 Energy (ATP) and metabolites 3 regulated steps.
Page 584 Glycolysis and TCA cycle: final accounting based on ~2.5 ATP/NADH and 1.5 ATP/FADH2 ~32 ATP/(glucose oxidized to 6CO2) Text – Figures, pg. 584.
Catabolism – Electron Transport. Catabolism -- Overview.
GLYCOLYSIS. O 2 absent O 2 present Glycolysis can be divided into two phases: priming and payoff Phase 1: five priming reactions 1. glucose + ATP G-6-P.
Pyruvate degradation occurs in the mitochondria © Michael Palmer 2014.
Glucose Metabolism: Glycolysis By Reem M. Sallam, M.D.; Ph.D. Assistant Prof., Clinical Chemistry Unit, Pathology Dept. College of Medicine, KSU
Metabolism in Skeletal Muscle Eric Niederhoffer SIU-SOM Glycolysis Glycogenolysis  -oxidation (ketone bodies) Krebs (tricarboxylic acid) cycle Branched-chain.
Lecture 13 Web: pollev.com/ucibio Text: To: Type in:
Storage Mechanisms and Control in Carbohydrate Metabolism Apr. 7, 2016 CHEM 281.
Fate of Pyruvate & Citric Acid Cycle
Gluconeogenesis ط Definition and Importance, ط Reactions and irreversibility ط Substrates : Glycerol, Lactate, Glucogenic amino acids, Odd chain fatty.
Glycolysis The conversion of glucose into 2 pyruvate molecules. Other sugars enter glycolysis at various steps and are also converted into 2 pyruvates.
Glycolysis: The Central Pathway of Glucose Degradation
Oxidative Decarboxylation and Krebs Cycle
Lecture on Glycolysis The Central Pathway of Glucose Degradation
Dr. Sooad Al-Daihan Biochemistry department
GLYCOLYSIS EMVB | HLY.
Glycolysis: The Central Pathway of Glucose Degradation
Glycolysis Glucose utilization in cells of higher plants and animals.
Glycolysis.
Coming up for air: HIF-1 and mitochondrial oxygen consumption
Aerobic respiration. Aerobic respiration. There are 4 major reaction pathways including glycolysis, the conversion of pyruvate to acetyl-CoA, the TCA cycle,
Glycolysis.
Presentation transcript:

Glycolysis during rest and exercise

Fates of Pyruvate Conversion to acetyl-CoA (oxidative phosphorylation) Lactate (glycolysis) AAT - increases TCA intermediates

Exercise Higher demand for ATP --> greater activation of enzymes that regulate glycolysis PHOS PFK HK Covalently and allosterically regulated by*: Hormones Ca2+ ATP *see 2nd PowerPoint for more information

At higher power outputs (higher demand for ATP) -->rate of pyruvate and NADH production exceed the ability of PDH to metabolize --> lactate production

Intensity of Exercise

Flux

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.