Aortic Intervention & Spinal Cord Ischemia Alexander J Gregory MD, FRCPC Department of Anesthesia, University of Calgary Calgary, Alberta, Canada May 30, 2014 Thoracic Aortic Rounds aorta.ca
OBJECTIVES
Cervical Plexus (Vertebrals) Hypogastric Plexus (Iliacs) Lumbar Segmentals Intercostal Segmentals
Risk
SCI incidence TAAA= 8-28% TAA= 2-3% TEVAR = 2-3% HAR = 0-4%
Risk Factors > 1 territory of blood supply lost Peri-operative hypotension Chronic renal failure Stent coverage Artery of Adamkiewicz sacrifice Atherosclerotic aorta Smoking Complicated Type-B, HAR & aortic transection Age
Risk Factors > 1 territory of blood supply lost Peri-operative hypotension Chronic renal failure ? Stent coverage ? Artery of Adamkiewicz sacrifice ?? Atherosclerotic aorta ?? Smoking ?? Complicated Type-B, HAR & aortic transection ?? Age
LSCA Bypass
Semin Thorac Cardiovasc Surg 2009; 21: Ishimaru Classification
Arm Ischemia
Vertebrobasilar Ischemia
SCI
Recommendation 1: In patients who need elective TEVAR where achievement of a proximal seal necessitates coverage of the left subclavian artery, we suggest routine preoperative revascularization, despite the very low-quality evidence (GRADE 2, level C). J Vasc Surg 2009;50:1155-8
Semin Vasc Surg 2012; 25:
Routine revascularization is unnecessary in the majority of patients requiring zone II coverage during thoracic endovascular aortic repair: A longitudinal outcomes study using United States Medicare population data. Wilson JE, Galiñanes EL, Hu P, Dombrovskiy Vym and Vogel TR. Vascular Sep 3. [Epub ahead of print] Medicare & Medicaid Services- Inpatient claims n= 2676 TEVAR, 869 LSCA covered, 49 LSCA bypassed TEVAR + LSCA w/out bypass = 1.9% bypassed in 1 st year TEVAR + LSCA + bypass = 12.8% vs 3.8% stroke & higher mortality
LSCA bypass Prophylactic LSCA bypass: LIMA AV fistula L hand dominance Supra-aortic or COW abnormalities LSCA bypass for clinically relevant malperfusion SCI does not appear to be substantially increased in most patients
Collateral Network
J Thorac Cardiovasc Surg 2011;141: = ASA = DP T L
J Thorac Cardiovasc Surg 2011;141:1020-8
J Thorac Cardiovasc Surg 2011;141:
Nat 24h 120h
J Thorac Cardiovasc Surg 2011;141:
J Thorac Cardiovasc Surg 2010;140:S125-30
T & L SA sacrifice
J Thorac Cardiovasc Surg 2010;140:S T & L SA sacrifice L only SA sacrifice
J Thorac Cardiovasc Surg 2010;140:S T & L SA sacrifice L only SA sacrifice T SA sacrifice 7d later
CSF Drains
Hanna et al , TEVAR, n=381 Prev aortic surgery + >75% + below T6 or Hybrid repair Crawford I-III Pre-op CSFd= 21% (81/381) Post-op CSFd for SCI= 1% (3/300) Group SCI= 6.6% (25/381), 1.8% (7/381) permanent Pre-op CSFd SCI= 14.8% (12/81), 7.4% (6/81) permanent No CSFd SCI= 4.3% (13/300), 0.3% (1/300) permanent CSFd complications= 11.1% (9/81), HA 5, leak 2, minor SDH 2 No CSF drained 32% (26/81) Keith et al , TEVAR, n=266 Pre-op CSFd excluded, post-op SCI protocol SCI= 6% (16/266), 3.4% (9/266) permanent CSFd req’d= 3.8% (10/266) CSFd reversed SCI= 30% (3/10) CSFd complications= 10% (1/10), SDH 1 Time of SCI onset to CSFd= 8.2 +/ hrs
Hanna et al , TEVAR, n=381 Prev aortic surgery + >75% + below T6 or Hybrid repair Crawford I-III Pre-op CSFd= 21% (81/381) Post-op CSFd for SCI= 1% (3/300) Group SCI= 6.6% (25/381), 1.8% (7/381) permanent Pre-op CSFd SCI= 14.8% (12/81), 7.4% (6/81) permanent No CSFd SCI= 4.3% (13/300), 0.3% (1/300) permanent CSFd complications= 11.1% (9/81), HA 5, leak 2, minor SDH 2 No CSF drained 32% (26/81) Keith et al , TEVAR, n=266 Pre-op CSFd excluded, post-op SCI protocol SCI= 6% (16/266), 3.4% (9/266) permanent CSFd req’d= 3.8% (10/266) CSFd reversed SCI= 30% (3/10) CSFd complications= 10% (1/10), SDH 1 Time of SCI onset to CSFd= 8.2 +/ hrs
Hanna et al , TEVAR, n=381 Prev aortic surgery + >75% + below T6 or Hybrid repair Crawford I-III Pre-op CSFd= 21% (81/381) Post-op CSFd for SCI= 1% (3/300) Group SCI= 6.6% (25/381), 1.8% (7/381) permanent Pre-op CSFd SCI= 14.8% (12/81), 7.4% (6/81) permanent No CSFd SCI= 4.3% (13/300), 0.3% (1/300) permanent CSFd complications= 11.1% (9/81), HA 5, leak 2, minor SDH 2 No CSF drained 32% (26/81) Keith et al , TEVAR, n=266 Pre-op CSFd excluded, post-op SCI protocol SCI= 6% (16/266), 3.4% (9/266) permanent CSFd req’d= 3.8% (10/266) CSFd reversed SCI= 30% (3/10) CSFd complications= 10% (1/10), SDH 1 Time of SCI onset to CSFd= 8.2 +/ hrs
Hanna et al , TEVAR, n=381 Prev aortic surgery + >75% + below T6 or Hybrid repair Crawford I-III Pre-op CSFd= 21% (81/381) Post-op CSFd for SCI= 1% (3/300) Group SCI= 6.6% (25/381), 1.8% (7/381) permanent Pre-op CSFd SCI= 14.8% (12/81), 7.4% (6/81) permanent No CSFd SCI= 4.3% (13/300), 0.3% (1/300) permanent CSFd complications= 11.1% (9/81), HA 5, leak 2, minor SDH 2 No CSF drained 32% (26/81) Keith et al , TEVAR, n=266 Pre-op CSFd excluded, post-op SCI protocol SCI= 6% (16/266), 3.4% (9/266) permanent CSFd req’d= 3.8% (10/266) CSFd reversed SCI= 30% (3/10) CSFd complications= 10% (1/10), SDH 1 Time of SCI onset to CSFd= 8.2 +/ hrs
Hanna et al , TEVAR, n=381 Prev aortic surgery + >75% + below T6 or Hybrid repair Crawford I-III Pre-op CSFd= 21% (81/381) Post-op CSFd for SCI= 1% (3/300) Group SCI= 6.6% (25/381), 1.8% (7/381) permanent Pre-op CSFd SCI= 14.8% (12/81), 7.4% (6/81) permanent No CSFd SCI= 4.3% (13/300), 0.3% (1/300) permanent CSFd complications= 11.1% (9/81), HA 5, leak 2, minor SDH 2 No CSF drained 32% (26/81) Keith et al , TEVAR, n=266 Pre-op CSFd excluded, post-op SCI protocol SCI= 6% (16/266), 3.4% (9/266) permanent CSFd req’d= 3.8% (10/266) CSFd reversed SCI= 30% (3/10) CSFd complications= 10% (1/10), SDH 1 Time of SCI onset to CSFd= 8.2 +/ hrs
Hanna et al , TEVAR, n=381 Prev aortic surgery + >75% + below T6 or Hybrid repair Crawford I-III Pre-op CSFd= 21% (81/381) Post-op CSFd for SCI= 1% (3/300) Group SCI= 6.6% (25/381), 1.8% (7/381) permanent Pre-op CSFd SCI= 14.8% (12/81), 7.4% (6/81) permanent No CSFd SCI= 4.3% (13/300), 0.3% (1/300) permanent CSFd complications= 11.1% (9/81), HA 5, leak 2, minor SDH 2 No CSF drained 32% (26/81) Keith et al , TEVAR, n=266 Pre-op CSFd excluded, post-op SCI protocol SCI= 6% (16/266), 3.4% (9/266) permanent CSFd req’d= 3.8% (10/266) CSFd reversed SCI= 30% (3/10) CSFd complications= 10% (1/10), SDH 1 Time of SCI onset to CSFd= 8.2 +/ hrs
CSFd Current FMC Strategy Selective use Intra-op CSF pressure 70 mmHg CSF drainage < 10 mL/hr SSEP Fast-track general anesthesia Post-op q1h neuro vitals Neuro normal= CSF pressure 65 mmHg SCI protocol