Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Is the Loose Anagen Hair Syndrome a Keratin Disorder?

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Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Is the Loose Anagen Hair Syndrome a Keratin Disorder? A Clinical and Molecular Study Arch Dermatol. 2002;138(4): doi: /archderm A, A typical trichogram showing almost only dystrophic anagen hairs. B, Detail showing ruffled cuticles and distorted bulbs. Figure Legend:

Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Is the Loose Anagen Hair Syndrome a Keratin Disorder? A Clinical and Molecular Study Arch Dermatol. 2002;138(4): doi: /archderm Pedigrees of families 2, 3, and 7 who are affected by loose anagen hair syndrome. DNA samples were obtained from all individuals. Black symbols indicate clinically affected members of the families; gray symbols, individuals who are clinically not affected but carry the K6HF E337K mutation; and open symbols, individuals who are not clinically affected and who do not carry the mutation. In family 7, diffuse partial woolly hair was diagnosed in I:1, II:1, II:2, and II:3. Figure Legend:

Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Is the Loose Anagen Hair Syndrome a Keratin Disorder? A Clinical and Molecular Study Arch Dermatol. 2002;138(4): doi: /archderm A patient with partial diffuse woolly hair. A, Clinical features showing a mixture of curly and straight hairs. B, Polarizing microscopy: torsion of a hair shaft in a woolly hair. Figure Legend:

Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Is the Loose Anagen Hair Syndrome a Keratin Disorder? A Clinical and Molecular Study Arch Dermatol. 2002;138(4): doi: /archderm Expression studies of K6hf and K6 in a follicle with loose anagen hair syndrome (LAHS). A near-longitudinal section of a follicle with LAHS was reacted with an antibody against K6hf (red) and K6 (green), as described by Winter et al. 6 ORS sb indicates outer root sheath, suprabasal; ORS b, outer root sheath, basal; cl, companion layer; co, cortex; and dp, dermal papilla. Figure Legend:

Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Is the Loose Anagen Hair Syndrome a Keratin Disorder? A Clinical and Molecular Study Arch Dermatol. 2002;138(4): doi: /archderm Mutation analysis of the type II keratin K6HF gene in family 3, affected by loose anagen hair syndrome. Excerpts from DNA sequencing gels show K6HF sequences from either unaffected individual I:1 (a) or affected individual II:1 (b). The affected individual is heterozygous for a silent C→T transition (solid arrow) and an adjacent G→A transition (open arrow), which leads to a E337K substitution in the L2 linker region of K6HF (amino acid residues S334 through W341). Figure Legend:

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