Characteristics and Visual Outcome of Patients With Retinal Vasculitis Ku JH, Ali A, Suhler EB, Choi D, Rosenbaum JT. Characteristics and visual outcome of patients with retinal vasculitis. Arch Ophthalmol. Published online June 11, doi: /archophthalmol Copyright restrictions may apply

Introduction Purpose –To examine the characteristics and visual outcome in 207 patients with retinal vasculitis. –To examine factors predictive of visual outcome in this population. Copyright restrictions may apply

Study Design –Retrospective medical record review. Study Population –207 cases of retinal vasculitis identified from 1390 patients attending the uveitis clinic at Oregon Health & Science University between 1985 and Copyright restrictions may apply Methods

Data Analysis –Frequencies of variables tabulated for descriptive analysis. –Kaplan-Meier method applied to compute proportions of visual acuity improvement as a function of follow-up time. –Cox proportional hazards model with shared-frailty controls for within- individual correlation. Copyright restrictions may apply Methods

75 eyes (36.9%) had visual acuity of 20/25 or better at baseline. 33.6% of eyes with visual acuity worse than 20/25 at baseline experienced visual acuity improvement of at least 2 lines on the Snellen chart during follow-up, and some continued to improve more than 9 years after the initial evaluation. Positive prognostic factors: nonwhite race, worse visual acuity at baseline, ocular infection. Negative prognostic factor: primary retinal vasculitis. Copyright restrictions may apply Results

Copyright restrictions may apply Results Characteristics of 207 Patients With Retinal Vasculitis

Copyright restrictions may apply Results Average LogMAR Change per Year in 203 Eyes With Retinal Vasculitis

Copyright restrictions may apply Results Kaplan-Meier curve demonstrating the cumulative proportion of eyes that had visual acuity improvement of ≥2 lines on the Snellen chart as a function of follow-up time in 203 eyes in 114 patients with retinal vasculitis who had visual acuity recorded at ≥2 points. Tick marks represent cases lost to follow-up; dotted lines, 95% CIs for survival proportions.

This is the first case series to examine visual outcome of retinal vasculitis in a population from North America. Limitations –Heterogeneity of retinal vasculitis. –Accuracy and consistency of data less than from a prospective study. –Patients had varying lengths of follow-up. –Data largely represent a northwestern US population. –Cases may be more severe than seen in primary clinics. Copyright restrictions may apply Comment

Work Under Way –Identifying subsets of retinal vasculitis and the prognosis of each subset. –Prognostic importance of associated physical and angiographic findings. Copyright restrictions may apply Comment

If you have questions, please contact the corresponding author: –Jennifer H. Ku, MPH, Casey Eye Institute, Oregon Health & Science University, 3181 Sam Jackson Park Rd SW, Portland, OR Funding/Support This work was supported by Research to Prevent Blindness, a core grant from the National Eye Institute, and funds from the Stan and Madelle Rosenfeld Family Trust, the William and Mary Bauman Foundation, and the William C. Kuzell Foundation. Copyright restrictions may apply Contact Information