Research on Potential Anti-Cancer Drugs Bill Denny Auckland Cancer Society Research Center Design drugs that intercalate between DNA bases. Structure?

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Research on Potential Anti-Cancer Drugs Bill Denny Auckland Cancer Society Research Center Design drugs that intercalate between DNA bases. Structure? Teixeira et al. (2005), work submitted for publication. Attack DNA => Attack fast dividing cells Cancer = Uncontrolled growth. Cells need DNA to divide.

Design drugs that intercalate between DNA bases. Structure? Research on Potential Anti-Cancer Drugs Bill Denny Auckland Cancer Society Research Center Christine Cardin, UK University of Reading Ricardo Leal ESRF/ILL/Keele University PhD student Trevor Forsyth ILL/Keele University Shirley Miles ILL/Keele University PhD student Deuteration Laboratory Ed Mitchell ESRF Teixeira et al. (2005), work submitted for publication. Susana Teixeira ILL/Keele University Postdoc

How drugs work: Zooming in on the structure! Drug Design Neutron ILL X-Ray DNA structure DNA: Fibers, Crystals, Solutions H – Bonds DNA distortion Sample Deuteration Lab.