NgBR is essential for endothelial cell glycosylation and vascular development by Eon Joo Park, Kariona A Grabińska, Ziqiang Guan, and William C Sessa EMBO.

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Presentation transcript:

NgBR is essential for endothelial cell glycosylation and vascular development by Eon Joo Park, Kariona A Grabińska, Ziqiang Guan, and William C Sessa EMBO Rep. Volume ():e January 11, 2016 ©2016 by European Molecular Biology Organization

Tie2 ‐ Cre ‐ mediated ablation of NgBR in endothelial cells impairs extraembryonic vascular development Eon Joo Park et al. EMBO Rep. doi: /embr ©2016 by European Molecular Biology Organization

NgBR endothelial KO embryos exhibit normal vascular development Eon Joo Park et al. EMBO Rep. doi: /embr ©2016 by European Molecular Biology Organization

Hemorrhages and reduced capillary density in inducible NgBR endothelial ‐ specific knockout embryos Eon Joo Park et al. EMBO Rep. doi: /embr ©2016 by European Molecular Biology Organization

Loss of NgBR decreases proliferation and increases apoptosis of endothelial cells Eon Joo Park et al. EMBO Rep. doi: /embr ©2016 by European Molecular Biology Organization

Normal pericyte coverage and no vessel regression in the NgBRi∆EC embryo Eon Joo Park et al. EMBO Rep. doi: /embr ©2016 by European Molecular Biology Organization

NgBRECKO and NgBRi∆EC embryos exhibit altered VEGFR2 glycosylation and partial rescue by Dol ‐ P supplementation Eon Joo Park et al. EMBO Rep. doi: /embr ©2016 by European Molecular Biology Organization

Dolichol level measurement and gene expression analysis in NgBR ‐ depleted tissues and cells Eon Joo Park et al. EMBO Rep. doi: /embr ©2016 by European Molecular Biology Organization

Nogo ‐ B is not required for NgBR functions in endothelial cells during embryogenesis Eon Joo Park et al. EMBO Rep. doi: /embr ©2016 by European Molecular Biology Organization