Daniel Janies, Ph.D. Carol Grotnes Belk Distinguished Professor of Bioinformatics and Genomics College of Computing and Informatics University of North.

Slides:

Advertisements

Similar presentations

Office of Infectious Diseases Computational Challenges for Infectious Diseases Michael Shaw, PhD OID/Office of the Director.

Advertisements

Research Issues in Animal Surveillance and Pandemic Planning Robert G. Webster, PhD Division of Virology Department of Infectious Diseases St. Jude Children’s.

Regional Health Focus Rome | 27 – 29 June |1 | Health Focus WHO Regional Perspective FAO/ OIE/ WHO Technical Meeting on Highly Pathogenic Avian.

Department of Molecular Virology and Microbiology Swine ‘09 The 2009 H1N1 Influenza Pandemic.

Avian Influenza – The Bird Flu

Protecting American Agriculture 1 Avian Influenza: Agricultural Perspectives & Interventions December 14, 2005.

Control of the H5N1 influenza epidemic at the source Patrick Woo.

Mmmmm Mohamed M. B. Alnoor CHP400 COMMUNITY HEALTH PROGRAM-II Avian Influenza H5N1 Epidemiology & Control mmmmm.

Genomic and Geographic Analysis of the Evolution and Spread of Infectious Disease Daniel Janies, Ph.D. Department of Biomedical informatics Ohio State.

University of Buffalo The State University of New York Spatiotemporal Data Mining on Networks Taehyong Kim Computer Science and Engineering State University.

State of the World Marian Baker BIO-340. An emergent disease is one that has appeared in a population for the first time, or that may have existed previously.

Clinical Outcomes of Influenza Infection Asymptomatic Asymptomatic Symptomatic Symptomatic  Respiratory syndrome - mild to severe  Involvement of major.

Avian Influenza – What does it all mean? Important Background Information Island Paravets and Residents.

Introduction to Genomics, Bioinformatics & Proteomics Brian Rybarczyk, PhD PMABS Department of Biology University of North Carolina Chapel Hill.

Viruses Small but deadly!. The Black Death o Also known as the Black Plague, was a devastating pandemic that first struck Europe in the mid-late-14th.

Issues of public health, infectious diseases The role of public health in the prevention of infectious diseases.

Final Notes Fera/JIFSAN 2012 Robert Edwards Chief Scientist Food and Environment Research Agency (Fera)

Issues of public health, infectious diseases and bioterrorism The role of public health in the prevention of infectious diseases.

How serious is the threat of an Avian flu Human Pandemic Avian (Bird) December 2005.

Emerging and Zoonotic Infectious Diseases

Developing a vaccine and how a pandemic could occur.

Bird Flu Mirna kambar. where they came from ? They came from Hong Kong in 1997.

Databases and tools to study the genomes of hundreds of pathogens, plants, and mammals Richard H. Scheuermann, Ph.D. Director of Informatics J. Craig Venter.

The BIO Directorate Microbial Biology Emphasis BIO Advisory Committee April, 2005.

Epidemiology Tools and Methods Session 2, Part 1.

Avian Influenza Political, Social, and Economic Dimensions of the Continuing Threat from Emerging Infectious Diseases.

NIAID Commitment to Influenza Research and Preparedness F. Gray Handley Associate Director for International Research Affairs National Institute of Allergy.

GAP Risk Assessment June Avian Influenza (Bird Flu) Three continents affected (Asia, Africa and Europe) Worrying situation in Indonesia, Egypt and.

Epidemiology Partners and Resources Session 2, Part 2.

Developed by the CDC Foundation :: cdcfoundation.org Note to presenter: You are welcome to include one, more or all of slides below in your presentation.

U.S. Dept. Agriculture Agricultural Research Service Rob Griesbach Technology Transfer Coordinator

KEY CONCEPT Some viral diseases can be prevented with vaccines.

Using Comparative Genomics to Explore the Genetic Code of Influenza Sangeeta Venkatachalam.

Food and Drug Administration

What’s up with the flu? Novel H1N1? SWINE FLU??? Mexican flu? swine-origin influenza A? A(H1N1)? S-OIV? North American flu? California flu? Schweingrippe.

Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint® Lectures Lectures by Greg Podgorski, Utah State University Preparing.

What do you need to know? Are you at risk? How do you protect yourself? SWINE FLU Partnership for Environmental Education and Rural Health peer.tamu.edu.

Avian Influenza When avian influenza hits will science have an efficient vaccine?

© 2005 Prentice Hall Inc. / A Pearson Education Company / Upper Saddle River, New Jersey “Bird flu”  Caused by avian influenza virus (AIV)  Endemic.

Emily Rinaldi Wildlife & Fisheries Biology 1 February 2013 Avian Influenza.

Epidemiology and Surveillance: Lessons from Past Pandemics Arnold S. Monto, MD Professor of Epidemiology University of Michigan School of Public Health.

1 U.S. Food and Drug Administration International Programs Melinda K. Plaisier Assistant Commissioner for International Programs U.S. Food and Drug Administration.

Integration of Host Factor Data into the Virus Pathogen Database and Analysis Resource (ViPR) and the Influenza Research Database (IRD) Brett E. Pickett.

Virion Structure and Organization

The Informatics Crystal Ball: Mining the Past to Predict the Species Jump Event 19 April 2011 Richard H. Scheuermann, Ph.D. Department of.

Infectious Diseases Unit 4 Lesson 4 plan. Do now What are the two ways a pathogen causes damage?

1 Prof Ian Brown Director of EU/OIE/FAO International Reference Laboratory for Avian Influenza Animal and Plant Health Agency-Weybridge (presented by Maria.

Pathogenomics How this project began: Ann Rose - take advantage of DNA sequence information - genomics Julian Davies - use the information to understand.

Viral Genomics: Strength in Numbers David Spiro Assistant Investigator J. Craig Venter Institute

Georgia Tech School of Biology Jung Ho Choi Born Seoul, Korea Came to US in 1965 – 3 rd grade B.S. Biology, MIT, 1978 Ph.D. Biology, UC San Diego,

The bird flu 刘真北京师范大学生命科学学院

ROLE OF CCR5 LEVELS IN HIV-1 EVOLUTION AND PATHOGENESIS ANJALI JOSHI Assistant Professor Center of Emphasis in Infectious Diseases Department of Biomedical.

Avian Influenza Prof Angus Nicoll, Influenza Co-ordinator Advisory Forum, September 2005.

Infectious Diseases Unit 4 Lesson 4 plan. Do now What are the two ways a pathogen causes damage?

VIRUSES SB13U Unit: Diversity of Living Things “The single biggest threat to man’s continued dominance on the planet is a virus.” —Joshua Lederberg, Nobel.

Lessons Learned and Novel Investigation Techniques in Response to a Large Community Outbreak of HIV-1 infection Philip J. Peters MD HIV Testing and Biomedical.

Evolution and transmission in HIV Steve Paterson Review; Rambaut 2004 Nature Reviews Genetics 5: ‘The causes and consequences of HIV evolution’

Final Assessment Refer to page 35 for instructions for your final writing piece.

Global Public Health Informatics Partnerships: Vision, Challenges and Progress Sherrilynne Fuller, Ph.D;* Debra Revere, MLIS, MA;* Ann Marie Kimball MD,

Hood College Master of Science in Bioinformatics (Proposed)

The Global Threat of Epidemic Emergent- Re-Emergent Infectious Diseases: Lessons Learned and Prospects for the Future S. Machado Duane J Gubler Professor.

KEY CONCEPT Some viral diseases can be prevented with vaccines.

Viruses Small but deadly!.

Professional Organizations

The role of the OIE in biological threat reduction

Public health measures toward prevention

KEY CONCEPT Some viral diseases can be prevented with vaccines.

KEY CONCEPT Some viral diseases can be prevented with vaccines.

KEY CONCEPT Some viral diseases can be prevented with vaccines.

Presentation transcript:

Daniel Janies, Ph.D. Carol Grotnes Belk Distinguished Professor of Bioinformatics and Genomics College of Computing and Informatics University of North Carolina at Charlotte Genes and geography of infectious diseases Analytics Frontiers Conference

Our goal is to develop means to analyze and share diverse types of data on pathogens

Pathogens underlying influenza like illness: UK, May 2000-April 2001 Creer et al., 2005

Pathogens underlying influenza like illness: Netherlands, November 1998 – June 2001

Chicago A B Toronto C Washington, DC Three cases of influenza like illness

If we sequence the genomes of the pathogens the three outbreaks can be interconnected and understood via their connections to background data

Where did the pathogen originate ? From Asia? From Europe? From South America?

Or did the pathogen originate in North America and will it spread abroad ? To Asia ? To Europe? To South America?

Which hosts carry a pathogen ?

Indonesia Korea and Japan Host taxa H5N1 influenza

Which trade processes carry a pathogen? chickens ducks smuggled eagle

Molecular Evolution of the Avian Influenza (H5N1) PB2 protein. This mutation confers increased replication in mammals

H7N PB2 E627K This mutation confers increased viral replication in mammals

Moon Fishery (India) Center for Food Safety and Applied Nutrition, US Food and Drug Administration

Next steps – genetic surveillance of infectious diseases US FDA, state and international partners

Global spread of Salmonella bareilly UNC joint work with US Food and Drug Administration University of Maryland University North Carolina at Charlotte Ohio State University New York State Department of Health Maryland Department of Health and Mental Hygiene

Salmonella bareilly, genetic tree, place metadata.

Africa, SE Asia, South Pacific, 2007-presentSouth America, Caribbean, present Global Spread of Zika Virus

Evolution of Zika’s envelope protein

Summary Our analyses can handle very large, diverse data sets. Results are visual and biomedical analytics that lead to actionable conclusions and new research directions. Meaningful use of heath IT, including commodity sequencing, will come from coordinated national and international efforts in infection control and biosurveillance.

Acknowledgements Organizers and Sponsors The Belk Family Defense Applied Research Projects Agency Defense Threat Reduction Agency US National Science Foundation University of North Carolina Game-Changing Research Fund UNC Charlotte: College of Computing and Informatics, Department of Bioinformatics and Genomics, Graduate School