William Sanford Karissa Thoma Dan Frost Allie Finney Client: Dr. Mark Reichelderfer Advisor: Dr. Willis Tompkins.

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An Audit of Endoscopic Complications in Adult Eosinophilic Esophagitis

Volume 117, Issue 1, Pages (July 1999)

Presentation transcript:

William Sanford Karissa Thoma Dan Frost Allie Finney Client: Dr. Mark Reichelderfer Advisor: Dr. Willis Tompkins

Overview 1.Background 2.Problem Statement 3.Design Constraints 4.Previous design work 5.Lab Jacks 6.Pressure Sensor Sealants 7.Future Work

Esophageal Strictures Dysphagia= dys  with difficulty +phagia  with eating Causes GERD majority 25% other problems Eosinophilic esophagitis UW-Hospital, Dr. Mark Reichelderfer

Eosinophilic Esophagitis Adolescents and young men History of food and environmental allergies Difficult to treat: Associated with mucosal tearing and perforation mo/contents/pt1/images/g imo49-f4.jpg

Dilation Balloon Dilates radially increasing lumen TTS scope (through the scope) Perforations Dependent on: Clinician’s experience Equipment JPG 2/esophageal_structures_s06/images/ba lloondialation.bmp

Problem Statement Measure pressure in balloon Graph volume/pressure curve in real time Obtain test data on tissue compliance Be aesthetically pleasing for hospital setting Eventually be commercially available

Design Constraints Work with current dilation procedure Provide real time data Safety Equip laptop for hospital use Provide warning of esophageal perforation Compact enough for hospital setting

Previous Work Syringe is filled with saline Pressure measured with disposable pressure transducer Volume measured with linear potentiometer Outputs are connected to computer Designed LabVIEW circuit for real time graph Seashore, K. et. al. (2006). Device for Dilating Esophageal Strictures.

LabVIEW Circuit

Lab Jacks-LabJack U12 Pros Built-in power supply Large input range LabVIEW compatible USB-based Cons Cost No -5V supply rodId=27

PMD-1208LS Pros USB Power supply LabVIEW compatible Cons No -5V supply Poor user interface zeuthen.desy.de/apewww/APE/hardware/APEmille/Temperat ure/PMD-1208LS.pdf

LabJack UE9 Pro Pros Wireless transmission USB LabVIEW compatible Cons Cost Bulky

WeightU12PMDUE9 Power Supply 2516 Inputs20 User friendly LabVIEW20 Size Cost10590 Total LabJack Matrix

Metal adhesives - MK 1325 Pros High strength Thread sealant Low viscosity Cons Irreversible From Germany a6b976cf39c2e4

Gorilla Glue Pros Waterproof Good for dissimilar surfaces Thread sealant Easy to obtain Cons Glue expansion

Megaloc Pros Psi strength Thread sealant Non-toxic Inexpensive Cons

Sealant Matrix 2 WeightMK 1325GorillaMegaloc Strength Reversibility10053 Toxicity20 Ease of use5455 Availability5153 Cost10?99 Total

Future Work Fix pressure sensor Obtain 10 atm seal Configure device with Lab Jack Configure to hospital laptop IRB approval/testing

References Fass, R. M. (2008). Approach to the patient with dysphagia. Retrieved Jan. 31, 2008 from Moises, G. M. (2008). Complications of esophageal stricture dilation. Retrieved Jan 31, 2008 from Moises, G. M. (2008). Management of benign esophageal strictures. Retrieved Jan , 2008 from