 >56,000 infected in the US in 2007  >37,000 diagnosed  Social stigma attached to HIV/AIDS  Transmitted through bodily fluids National Institutes.

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Presentation transcript:

 >56,000 infected in the US in 2007  >37,000 diagnosed  Social stigma attached to HIV/AIDS  Transmitted through bodily fluids National Institutes of Health, 2008

cellular-immunity.blogspot.com/.../hivaids.html

 Viral Transmission - Casual v. Intentional  Scientific Evidence  Previous Cases Florida Dental Case (Ho et al., 1995) State of Louisiana vs. Richard J. Schmidt (Metzker et al., 2002) State of Washington vs. Anthony E. Whitfield (Scaduto et al., pending submission)

No Precedent in the state of Texas

 Approved Protocol  Blinded study  Samples separated spatial and temporally  Phylogenetic Analysis  DNA sequence analysis of 2 gene regions ▪ Reverse Transcriptase = “RT” ▪ GP120 = “ENV”  Case samples compared to controls

HIV-1 DNA sequences obtained from Phillippe Padieu and the women identified through the course of the investigation are more closely related to each other than to unrelated HIV-1 DNA sequences

Plasma WBCs RBCs lysePCR RT ENV Clone Anonymous Whole Blood gDNA Sequence by Sanger

RT Evolutionary TreeENV Evolutionary Tree

RT Evolutionary Tree

ENV Evolutionary Tree

 CC01: Philippe Padieu  CC02:Female partner  CC03:Female partner  CC04: Female partner  CC05:Female partner  CC06:Female partner

Guilty on ALL Six Counts!

Scaduto et al., PNAS , (December 14, 2010).

 Michael Metzker, Ph.D.  David Hillis, Ph.D.  Jeremy M. Brown, Ph.D.  Collins County District Attorney’s Office  Asst. District Attorney Lisa Milasky King  Collins County Police Department  Criminal Investigator Samme Glasby  Lourdes Fernandez  3R21HG S1/-02S2