Date of download: 6/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Implantable Cardioverter Defibrillators and Quality of Life: Results From the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation Study Arch Intern Med. 2007;167(20): doi: /archinte Unadjusted health-related quality-of-life (HRQL) scores over time on the subscales of the Minnesota Living With Heart Failure Questionnaire (MLHFQ) and the 12-Item Medical Outcomes Short-Form Health Survey (SF-12) for patients randomized to treatment with an implantable cardioverter defibrillator (ICD) and standard medical therapy (STD). Directions of the scales have been standardized so that the vertical axis represents increasing HRQL for all subscales. A, Physical scale of the MLHFQ. B, Emotional scale of the MLHFQ. C, Physical component score (PCS) of the SF-12. D, Mental component score (MCS) of the SF-12. The upper range of the y-axis for the SF-12 has been reduced from the traditional 100 points to 65 points, as more than 95% of all recorded values fell within a narrow range near the midpoint of the scale. Confidence intervals for HRQL scores obtained later in the study were wider owing to the declining numbers of patients providing HRQL data and the increased heterogeneity of those scores. Error bars represent 95% confidence intervals. Figure Legend:

Date of download: 6/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Implantable Cardioverter Defibrillators and Quality of Life: Results From the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation Study Arch Intern Med. 2007;167(20): doi: /archinte The 12-Item Medical Outcomes Short-Form Health Survey (SF-12) scores adjusted by time in trial by treatment group. The modeled changes in health-related quality-of-life (HRQL) on the mental component score (MCS) and the physical component score (PCS) of the SF-12 throughout the trial are shown. The y-axis represents the mean SF-12 score, with the full scale ranging from 0 to 100. Higher scores represent better HRQL. Figure Legend:

Date of download: 6/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Implantable Cardioverter Defibrillators and Quality of Life: Results From the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation Study Arch Intern Med. 2007;167(20): doi: /archinte Minnesota Living With Heart Failure Questionnaire (MLHFQ) scores adjusted by time in trial by treatment group. A, The modeled changes in health-related quality-of-life (HRQL) on the emotional scale of the MLHFQ are shown. The y-axis represents the 50th through 100th percentiles of the 0- to 25-point emotional scale. B, The modeled changes in HRQL on the physical scale of the MLHFQ are shown. The y-axis represents the 50th through 100th percentiles for the 0- to 40-point physical scale. Decreasing scores represent a better HRQL for both measures. ICD indicates implantable cardioverter defibrillator; STD, standard medical therapy. Figure Legend:

Date of download: 6/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Implantable Cardioverter Defibrillators and Quality of Life: Results From the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation Study Arch Intern Med. 2007;167(20): doi: /archinte Impact of shocks on health-related quality-of-life (HRQL): mean change and percentage of overall score. The direction of the scales has been normalized so that positive values represent a lower HRQL. The mean HRQL differed significantly compared with preshock values for the emotional scale of the MLHFQ and the mental component scale (MCS) of the 12-Item Medical Outcomes Short-Form Health Survey (SF-12) (asterisks, P =.04 for comparison with preshock HRQL). However, these changes represent a small component of each total score (< 2.0% for each). Error bars represent 95% confidence intervals. Emotional indicates the emotional score on the Minnesota Living With Heart Failure Questionnaire (MLHFQ); Physical, the physical score on the MLHFQ; and PCS, the physical component score on the SF-12. Figure Legend: