1 Common Names of Heterocyclic Amines If the nitrogen atom occurs as part of a ring, the compound is designated as being heterocyclic Each ring system has its own parent name

2

3 Table 24-1a, p. 923

4 Table 24-2, p. 926

5 S N 2 Reactions of Alkyl Halides Ammonia and other amines are good nucleophiles

6 Uncontrolled Multiple Alkylation Primary, secondary, and tertiary amines all have similar reactivity, the initially formed monoalkylated substance undergoes further reaction to yield a mixture of products

7 Mechanism of Reductive Amination

8 Reductive Amination Is Versatile Ammonia, primary amines, and secondary amines yield primary, secondary, and tertiary amines, respectively

9 Reductive Amination of Aldehydes and Ketones Treatment of an aldehyde or ketone with ammonia or an amine in the presence of a reducing agent

Reactions of Amines Alkylation and acylation have already been presented Fast Slow

11 Hoffman Elimination Good Leaving Group E2

12 Get Hoffman pdt not Zaitsev pdt.

Heterocycles A heterocycle is a cyclic compound that contains atoms of two or more elements in its ring, usually C along with N, O, or S

14 Polycyclic Heterocycles

15 IR of Amines

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