Induction of cyclin E–cdk2 kinase activity, E2F ‐ dependent transcription and cell growth by Myc are genetically separable events by Rudolf Beier, Andrea.

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Induction of cyclin E–cdk2 kinase activity, E2F ‐ dependent transcription and cell growth by Myc are genetically separable events by Rudolf Beier, Andrea Bürgin, Astrid Kiermaier, Matthew Fero, Holger Karsunky, Rainer Saffrich, Tarik Möröy, Wilhelm Ansorge, Jim Roberts, and Martin Eilers EMBO J. Volume 19(21): November 1, 2000 ©2000 by European Molecular Biology Organization

Immortalization and induction of apoptosis by Myc in primary p27+/+ and p27−/− MEFs. (A) Number of colonies growing upon infection of either p27−/− or p27+/+ cells with control (‘pbabe’) or Myc ‐ expressing virus (‘pbabe ‐ Myc’), after selection with puromycin... Rudolf Beier et al. EMBO J. 2000;19: ©2000 by European Molecular Biology Organization

Rudolf Beier et al. EMBO J. 2000;19: ©2000 by European Molecular Biology Organization

Rudolf Beier et al. EMBO J. 2000;19: ©2000 by European Molecular Biology Organization

Failure of Myc to activate cyclin E ‐ dependent kinase in p27−/− cells. Rudolf Beier et al. EMBO J. 2000;19: ©2000 by European Molecular Biology Organization

Activation of E2F ‐ dependent genes by Myc is independent of p27. Rudolf Beier et al. EMBO J. 2000;19: ©2000 by European Molecular Biology Organization

Activation of cyclin A–cdk2 kinase activity by Myc in p27−/− MycER cells. Rudolf Beier et al. EMBO J. 2000;19: ©2000 by European Molecular Biology Organization

Rudolf Beier et al. EMBO J. 2000;19: ©2000 by European Molecular Biology Organization

Rudolf Beier et al. EMBO J. 2000;19: ©2000 by European Molecular Biology Organization

Activation of E2F2 promotes cell cycle progression, but not cell growth. Rudolf Beier et al. EMBO J. 2000;19: ©2000 by European Molecular Biology Organization