Date of download: 6/17/2016 From: Treatment of Rheumatoid Arthritis with Gammalinolenic Acid Ann Intern Med. 1993;119(9):867-873. doi:10.7326/0003-4819-119-9-199311010-00001.

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Date of download: 6/17/2016 From: Treatment of Rheumatoid Arthritis with Gammalinolenic Acid Ann Intern Med. 1993;119(9): doi: / Metabolic pathway of omega-6 (n-6) fatty acids The pathway is one of progressive desaturation alternating with elongation (addition of two carbons). 18:2 = 18 carbons, 2 double bonds; (150H) DGLA = 15 hydroxy dihomogamma linolenic acid; LTC = leukotriene C ; LTB = leukotriene B ; PGE = prostaglandin E ; TXA = thromboxane A. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/17/2016 From: Treatment of Rheumatoid Arthritis with Gammalinolenic Acid Ann Intern Med. 1993;119(9): doi: / Joint tenderness scores in patients completing the study.nnMean percentage change from baseline at each evaluation for placebo (open squares; = 13) and gammalinolenic acid (GLA) treatment (closed squares; = 14) groups. Error bars are 1 standard error of the mean. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/17/2016 From: Treatment of Rheumatoid Arthritis with Gammalinolenic Acid Ann Intern Med. 1993;119(9): doi: / Joint swelling scores in patients completing the study.nnMean percentage change from baseline at each evaluation for placebo (open squares; = 13) and gammalinolenic acid (GLA) treatment (closed squares; = 14) groups. Error bars are 1 standard error of the mean. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

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