Dr. Aneela javed IMMUNOPATHOLOGY AND IMMUNOTHERAPY (BPH-375) Credit Hrs 3(2-1)

mmunopathology is a branch of medicine that deals with immune responses associated with disease. It includes the study of the pathology of an organism, organ system, or disease with respect to the immune system, immunity, and immune responses. IMMUNOPATHOLOGY IMMUNOTHERAPY the prevention or treatment of disease with substances that stimulate the immune response.

Students will also learn about the possible ways intervening with such process by modulating the immune system i.e. by inducing, suppressing or enhancing the immune system.

Course Contents The basis of immunology, Antigen recognition and response of immune system Tolerance: immunological principles of tolerance: central versus peripheral tolerance, role of regulatory T cells, natural killer T cells, dendritic cells Autoimmune diseases: description and pathogenesis, role of autoantibodies Autoimmune response and immune tolerance, Priming regulatory t cells and antigen specific suppression of autoimmune diseases, Peripheral t cell regulation and autoimmunity, Antiergotypic regulation of immune response

Immune regulation in various autoimmune diseases (AID) and immunotherapeutic approaches 1.Diabetes 2.Multiple sclerosis 3.Inflammatory bowel disease 4.Arthritis 5.Hematological autoimmune disorders 6.Other autoimmune disorders 7.Systemic Lupus Erythematosus 8.Sjögren Syndrome Immune mediated inflammatory disorders: role of TNF, role of other inflammatory pathways, identification of therapeutic targets Allergy and asthma: role of inflammatory cells and immune cells; role of mediators; therapeutic targets

Immunotherapy: overview of immunotherapies (small molecules, biologicals): principles, indications, side effects T cell therapy Non-T cell therapy Use of dendritic cells in immunotherapy Tumor Immunology Cancer immunotherapy

Recommended Books: Innate immune regulation and cancer immunotherapy by Rongful Wang Immunology, Immunopathology and Immunity by S. Sell Really Essential Medical Immunology by Arthur Rabson, Ivan Roitt Experimental and applied immunotherapy by Jeffrey Medin and Daniel Fowler Immune regulation and immunotherapy in autoimmune diseases, By Jingwu Zhang Heat shock protein and whole body physiology by Alexzander A.A. Asea, Bente K edersen Immunotherapy for infectious diseases by Jeffrey M. Jacobson Experimental and applied immunotherapy by Jeffrey Medin

Lab Work: Serological tests [Screening &diagnostic] used in different pathological conditions. Blood grouping &cross matching. Coomb’s Test - Direct & Indirect Mouse dissection and lymph node isolation Isolation and analysis of mouse spleen cells Isolation and analysis of mouse bone marrow cells Generation of mouse polyclonal antibodies Analysis of skin resident dendritic cell population Analysis of various lymphocyte populations via FACS Dendritic cells Macrophages T cells B cells

1.2 OHTs….skip rule…. makeup 2.6 quiz/surprise test…no makeup 3.Class participation…. 4.Assignments/Presentation /project

Basic Immunonology

CD8 mediated non cytolytic response

AIDS