Professor Dr. R. K. Mahanta, Department of Biochemistry, Jorhat Medical College The Voyage From The Universe into Biochemistry

Guidelines for Users  The materials presented are neither text material nor notes for the students.  They should not be treated as substitute for the text books on the subject and topics.  These are presented and released for the students only as post delivery reference on the topics covered in the classes for the students.  The optimum benefit and use will be archived only by the students who had actually attended these classes covering the topics.  Use of the material without attending the classes may confuse and mislead the student.  In case of arising confusion, go through the available test book or reference material and try to overcome the confusion reasonably.  In situations of persistent confusion and controversy, the student is advised to contact the Professor and Head of the Department of Biochemistry, Jorhat Medical College personally.

From The Universe into Biochemistry

The First Step

What is Universe?

Universe is the total interactive entity of Space-Time-Energy-Mater

Components of Universe Space Time Energy Mater

Laws of Universe The fundamental laws of Physics, Chemistry and Thermodynamics is uniformly and equally followed in each and every part of the Universe without any discrimination

Behavior of Components Under the fundamental laws of Universe For space, time and energy behavior is similar in the entire Universe But for mater it is not similar in different portions of the Universe For matter there are two types of behavior

Two basic behavior of matter Living Non living

Study of Universe Biology is the branch that study the behavior of the living part of the universe

What is Biochemistry? Biochemistry is studying how some part of the Universe behaves as living

The Steps into BIOCHEMISTRY

Introduction to Biochemistry The Biology of Molecules

Basically Biology is Study of Living Materials

Biology of Molecules is Study of Living Molecules

Study of Living Molecule is Molecularbiology

Biochemistry is Misnomer for Molecularbiology Biochemistry Represents only a fraction of Molecularbiology

We study The total Biology of living Molecules It is not the fraction of chemistry involved in Living Therefore we study Molecularbiology not Biochemistry

Biochemistry – Molecular biology The scientific discipline that study the molecular behavior under interactive universal physicochemical forces associated with formation, maintenance and replication of living systems and character of molecules originating in living systems

The scientific discipline that study the molecular behavior Under interactive universal physicochemical forces Associated with formation, maintenance and replication of living systems And character of molecules originating in living systems Definition components

We study molecular behavior associated with life But What is LIFE?

Let us try to define Life in the perspective of Molecularbiology

Life-Living system –Living process Life is the cumulative chronological outcome of a thermodynamically open isothermal, dynamic, non equilibrating physicochemical system characterized with capacity for precise self assembly, self regulation and self replication with maintenance of system enthalpy at the expense of exponential increase in extra system entropy modulated by information molecules for system regulation and transmittable during system replication and system recombination to increase system durability

Definition components Cumulative chronological outcome Thermodynamically open isothermal, dynamic, non equilibrating physicochemical system Capacity for precise self assembly, self regulation and self replication Maintenance of system enthalpy at the expense of exponential increase in extra system entropy Modulated by information molecules for system regulation Transmittable during system replication and system recombination To increase system durability

The living systems The demarcated volume of universe with characters of life is designated as a living system. The dynamic molecular bilayer that separates the system from the environment is the system membrane.

The Living Process and State The events going on in a living system is the living process. The dynamic non equilibrating stage of the system is the living state.

The Events and Participants The chemical changes and events in the living system is metabolism. The molecules taking part in system maintenance are the metabolites

Deviations, Remedies and Outcome Deviation of system status towards equilibrium is disease. Procedures taken to revert back system deviations towards evolutionally accepted status is treatment. Irreversible system deviation producing system equilibrium is death.

Our Targeted Objective To procure adequate information over principles and tools of Molecularbiology to explore and exploit the fundamentals of Living System and the Process, for improvement of quality in human health and society.

Thanks It is a protein bubble