Platelet activation and inhibition in polycythemia vera and essential thrombocythemia by Carlo Patrono, Bianca Rocca, and Valerio De Stefano Blood Volume.

Slides:

Advertisements

Similar presentations

Circulation Research February 2013 Journal Club Circulating MicroRNAs as Novel Biomarkers for Platelet Activation Peter Willeit, Anna Zampetaki, Katarzyna.

Advertisements

Effect of Aspirin Dose on Platelet Reactivity in Diabetic Patients Effect of Aspirin Dose on Platelet Reactivity in Diabetic Patients Paul A. Gurbel, MD.

Aspirinn doses in diabetics - AngiolilloSlide 1 Davide Capodanno, MD, Aasita Patel, MD, Kodlipet Dharmashankar, MD, José Luis Ferreiro, MD, Masafumi Ueno,

Dose- and time-dependent antiplatelet effects of aspirin Christina Perneby, N. Håkan Wallén, Cathy Rooney, Desmond Fitzgerald, Paul Hjemdahl Published.

THROMBOTIC COMPLICATIONS IN PATIENTS WITH POLYCYTHEMIA VERA Coordinator: Asist. Univ. Dr. Marcela Candea Authors: Ioana-Violeta Oltean Ioana Barsan Madalina.

High incidence of antibodies to protamine and protamine/heparin complexes in patients undergoing cardiopulmonary bypass by Grace M. Lee, Ian J. Welsby,

Myeloproliferative Disorders (MPD) concepts Neoplastic (clonal) disorders of hemopoietic stem cells Over-production of all cell lines, with usually one.

Increased peripheral platelet destruction and caspase-3– independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients by.

Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome by Jacob H. Rand,

Rivaroxaban Has Predictable Pharmacokinetics (PK) and Pharmacodynamics (PD) When Given Once or Twice Daily for the Treatment of Acute, Proximal Deep Vein.

The angiogenesis inhibitor vasostatin is regulated by neutrophil elastase–dependent cleavage of calreticulin in AML patients by Sarah Mans, Yara Banz,

Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13): December 15, 2008 ©2008 by American Society of Hematology.

Mechanism of Action of Aspirin Carlo Patrono, et al, N Engl J Med 2005;353:

A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease Marie.

Dosing lepirudin in patients with heparin-induced thrombocytopenia and normal or impaired renal function: a single-center experience with 68 patients by.

Date of download: 6/1/2016 Copyright © The American College of Cardiology. All rights reserved. From: Patients With Poor Responsiveness to Thienopyridine.

How I treat HHV8/KSHV-related diseases in posttransplant patients by Giovanni Riva, Mario Luppi, Patrizia Barozzi, Fabio Forghieri, and Leonardo Potenza.

Date of download: 6/21/2016 Copyright © The American College of Cardiology. All rights reserved. From: Pharmacodynamic interaction of naproxen with low-dose.

Time from diagnosis to treatment initiation predicts survival in younger, but not older, acute myeloid leukemia patients by Mikkael A. Sekeres, Paul Elson,

by Paul A. Carpenter, Meei-Li Huang, and George B. McDonald

Microalbuminuria in essential hypertension: Significance, pathophysiology, and therapeutic implications Stefano Bianchi, MD, Roberto Bigazzi, MD, Vito.

The Prognostic Value Of Dynamic Monitoring C-Reactive Protein (CRP) Serum Levels In NK/T-Cell Lymphoma by Bing Bai, Qi-chun Cai, Xiao-Xiao Wang, Qingqing.

by Robert A. Kyle, Morie A. Gertz, Philip R. Greipp, Thomas E

Chronic Myeloproliferative Neoplasms (MPN) Ph-negative

Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells by Toshihiko Tanno, Yiting Lim, Qiuju.

A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma Blood Volume 89(11): June 1, 1997 ©1997.

Rearranged Ig Heavy Chain DNA Is Detectable in Cell-Free Blood Samples of Patients With B-Cell Neoplasia by N. Frickhofen, E. Müller, M. Sandherr, T. Binder,

How I treat elderly patients with myeloma

Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in healthy human volunteers by.

Relationship between urinary TNF-α and RANTES excretion

Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors by Peter B. Anning, Barbara Coles, Jonathan Morton, Haibin Wang, Jashim.

by Daniel W. Bougie, Ana I. Benito, Luis I

Polycythemia vera following autologous transplantation for AML: insights on the kinetics of JAK2V617F clonal dominance by Elisabetta Antonioli, Paola Guglielmelli,

JAK2V617F mutation and hydroxyurea treatment as determinants of immature platelet parameters in essential thrombocythemia and polycythemia vera patients.

Thrombocythemia and polycythemia in patients younger than 20 years at diagnosis: clinical and biologic features, treatment, and long-term outcome by Fiorina.

Ayalew Tefferi, MD, Tiziano Barbui, MD Mayo Clinic Proceedings

Increased Phagocyte FcγRI Expression and Improved Fcγ-Receptor–Mediated Phagocytosis After In Vivo Recombinant Human Interferon-γ Treatment of Normal Human.

Solitary plasmacytoma of bone and asymptomatic multiple myeloma

Relationship between hepatocellular injury and transfusional iron overload prior to and during iron chelation with desferrioxamine: a study in adult patients.

by James D. Cook, Carol H. Flowers, and Barry S. Skikne

by Douglas D. Ross, Judith E. Karp, Tar T. Chen, and L. Austin Doyle

ROCK and Rho(ll) in bone marrow

Chronic neutropenia mediated by Fas ligand

Human NK cells can control CMV infection in the absence of T cells

by Paul A. Carpenter, Meei-Li Huang, and George B. McDonald

by Jon E. Arnason, Federico Campigotto, Donna Neuberg, and James B

Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study by Samantha C. Gouw,

Inhibitory mechanisms of very low–dose rivaroxaban in non–ST-elevation myocardial infarction by Oliver Borst, Patrick Münzer, Nada Alnaggar, Sascha Geue,

Volume 141, Issue 2, Pages e89S-e119S (February 2012)

Increased Formation of ThromboxaneIn Vivo in Humans with Mastocytosis

James F. List, Jean M. Whaley Kidney International

Volume 120, Issue 4, Pages (March 2001)

Predicted number of joint bleeds according to factor activity level and age group for patients with hemophilia A or B based on a regression model. Predicted.

A phase 1 trial evaluating thioridazine in combination with cytarabine in patients with acute myeloid leukemia by Lili Aslostovar, Allison L. Boyd, Mohammed.

Regulation by Interleukin-10 and Interleukin-4 of Cyclooxygenase-2 Expression in Human Neutrophils by Hiroaki Niiro, Takeshi Otsuka, Kenji Izuhara, Kunihiro.

by Wendy Lim, Sara K. Vesely, and James N. George

Overcoming “aspirin resistance” in MPN

A and B: Flow cytometric analysis of the effect of MRP-8/14 in the serum of a type 1 diabetic patient on the surface expression of CD11b and CD118. A and.

(A) Primary platelet reactivity outcome: difference in platelet reactivity units (PRU) after treatment between triple antiplatelet therapy (TAPT) versus.

Erratum in Ledru et al. Alteration of tumor necrosis factor–α T-cell homeostasis following potent antiretroviral therapy: contribution to the development.

Volume 141, Issue 2, Pages e89S-e119S (February 2012)

JAK2 or CALR mutation status defines subtypes of essential thrombocythemia with substantially different clinical course and outcomes by Elisa Rumi, Daniela.

Time-dependent survival estimation in post–polycythemia vera myelofibrosis. Time-dependent survival estimation in post–polycythemia vera myelofibrosis.

Representative staining of bone marrow aspirates collected from a patient at baseline and after 1 cycle of treatment with 45 mg/m2 selinexor + 20 mg dexamethasone,

A binding relationship with thrombin

Distribution of percent consistent facility aspirin use.

Pure red cell aplasia by Robert T. Means Blood

Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined significance. #Mayo Clinic Risk.

Correlation between urinary albumin excretion rate and expression of platelet surface markers, active GPIIb/IIIa, and P-selectin. Correlation between urinary.

Patient Tregs express normal levels of suppression.

Presentation transcript:

Platelet activation and inhibition in polycythemia vera and essential thrombocythemia by Carlo Patrono, Bianca Rocca, and Valerio De Stefano Blood Volume 121(10): March 7, 2013 ©2013 by American Society of Hematology

Rate of TXB2 production in healthy subjects (A) and urinary excretion rates of 11-dehydro-TXB2 in clinical settings at high cardiovascular risk. Carlo Patrono et al. Blood 2013;121: ©2013 by American Society of Hematology

Estimated rates of upper gastrointestinal complications in men, according to age and the presence or absence of a history of such complications and regular treatment with low-dose aspirin. Carlo Patrono et al. Blood 2013;121: ©2013 by American Society of Hematology

Recovery of serum TXB2 after aspirin withdrawal in healthy subjects. Carlo Patrono et al. Blood 2013;121: ©2013 by American Society of Hematology

Model of altered aspirin pharmacodynamics in ET. Under conditions of normal megakaryopoiesis, low-dose aspirin acetylates COX isozymes in both circulating platelets and bone marrow megakaryocytes, and only negligible amounts of unacetylated enzymes are resy... Carlo Patrono et al. Blood 2013;121: ©2013 by American Society of Hematology

Principle and kinetics of the serum TXB2 ex vivo assay. Carlo Patrono et al. Blood 2013;121: ©2013 by American Society of Hematology

Correlations between biochemical and functional assays of platelet response to aspirin in healthy subjects and patients with ET. Individual percent inhibition values are depicted from healthy volunteers (n = 48) during aspirin treatment (100 mg daily) and f... Carlo Patrono et al. Blood 2013;121: ©2013 by American Society of Hematology