Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization by Viola Lorenz, David Stegner, Simon Stritt, Timo Vögtle, Friedemann.

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Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization by Viola Lorenz, David Stegner, Simon Stritt, Timo Vögtle, Friedemann Kiefer, Walter Witke, Jürgen Schymeinsky, Steve P. Watson, Barbara Walzog, and Bernhard Nieswandt Blood Volume 125(26): June 25, 2015 ©2015 by American Society of Hematology

INU1-induced thrombocytopenia depends on platelet CLEC-2 expression. Viola Lorenz et al. Blood 2015;125: ©2015 by American Society of Hematology

INU1-induced thrombocytopenia is independent of platelet integrin activation and FcγRs. Viola Lorenz et al. Blood 2015;125: ©2015 by American Society of Hematology

Syk is required for INU1-induced thrombocytopenia. Viola Lorenz et al. Blood 2015;125: ©2015 by American Society of Hematology

CLEC-2 downregulation occurs through Syk-independent internalization. Viola Lorenz et al. Blood 2015;125: ©2015 by American Society of Hematology

CLEC-2 internalization depends on SFK activity. Viola Lorenz et al. Blood 2015;125: ©2015 by American Society of Hematology

INU1-induced CLEC-2 internalization in fetal liver–derived MKs. The livers of to 14.5-day- old mouse embryos were isolated from time-mated mice and a single-cell suspension was cultured for 72 hours; mature MKs were enriched on day 3 of culturing using... Viola Lorenz et al. Blood 2015;125: ©2015 by American Society of Hematology