Immunogenetics chapter 21 pp. pp. 620-627. Lines of Defense Physical and Chemical Physical and Chemical Immune system Immune system 3 rd line 1 st and.

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Immunogenetics chapter 21 pp. pp

Lines of Defense Physical and Chemical Physical and Chemical Immune system Immune system 3 rd line 1 st and 2 nd lines

First line of defense First line of defense

Second line of defense Second line of defense

3 rd line of defense “The Immune System”

Summary Lines of Defense

Immune System B cells T cells

Lymph nodes are contain high concentrations lymphocytes

Let’s now look at the specific lymphocytes that reside in these nodes.

B Cell Humoral Immunity Humoral Immunity –Antibody Mediated

The Antibody

Antibody Diversity How do we acquire so many different types of antibodies? How do we acquire so many different types of antibodies? –Somatic recombination –Junctional diversity –hypermutations

Somatic Recombination munology/Flash/somaticrecomb.html munology/Flash/somaticrecomb.html munology/Flash/somaticrecomb.html munology/Flash/somaticrecomb.html

Antibody genes are composed of segments V J C

Antibody Production and Vaccinations

Antibody Production

Vaccinations Passive vaccines Passive vaccines Active vaccines Active vaccines

T Cells VJC (D)

T cells classification Helper T Cell Helper T Cell Cytotoxic T Cells Cytotoxic T Cells Memory T Cells Memory T Cells CD4+ CD4+ CD8+ CD8+

Cytotoxic T cell= CD8+

The major histocompatibility complex is a large group of genes on chromosome 6 is a large group of genes on chromosome 6

Tissue Transplantation MHC proteins differ between individuals MHC proteins differ between individuals

2 types of MHC MHC I MHC I MHC II MHC II CD8+ cells recognizes endogenous antigens CD8+ cells recognizes endogenous antigens CD4+ cells recognizes exogenous antigens CD4+ cells recognizes exogenous antigens

Cytotoxic T Cell and MHC I Antigen presentation CD8+ cell

Cytotoxic T cell= CD8+

2 types of MHC MHC I MHC I MHC II MHC II CD8+ cells recognizes endogenous antigens CD8+ cells recognizes endogenous antigens CD4+ cells recognizes exogenous antigens CD4+ cells recognizes exogenous antigens

Helper T Cell and MHC II Antigen presentation

B lymphocytes source of antibodies Overview of T lymphocytes

Cancer cell being attacked by cytotoxic T cells After release of perforin

Onto our discussion of cancer genetics

Allergic Response I.

Allergic Response II.

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