Andrei MIHAILESCU, Ashraf RASHEED Royal Gwent Hospital, Newport This simple small size retrospective study highlighted the lack of a validated comparative tool for such a common surgical procedure. The youngest patient was a female age 14, the oldest was a male at the age of 86. Under the age of 50, the operated female/male ratio is significantly over the general F/M ratio (5.2/1 vs. 3.5/1), confirming the fact that female patients develop the disease in younger ages. The female/male ratio for patients who underwent emergency operation was less than the general F/M ratio hence the chance of a male to need an emergency intervention is higher ( F/M general 3.5/1 vs. F/M emergency 2.7/1 ). This suggests that the males developing gall stone disease experience worse manifestations than the females. The female to male ratio in this cohort is 3.5 / 1 Interventions on females over 75 years of age lasted an average of 29 minutes more than interventions on males from same age group. In regards to the significant intra-operative findings, it was interesting to note that a shrunken GB was found frequently in males (1.4/1 F/M ratio compared with General F/M ratio of 3.5/1) and sub-total cholecystectomies were performed in more occasions in males than in females. (12 M cases vs. 10 F cases despite 3.5/1 F/M ratio in the cohort). More males had gangrenous GB than females, so progression to perforation in males is more likely to happen after severe cholecystitis than in females. This is confirmed by the finding of equal number of gall bladder abscesses in both sexes, despite the total no. of females being 3.5 times higher. The ratio of both open and laparoscopic exploration of bile ducts needed was much higher than in female patients than general ratio (L-TCE, O-TCBDE /1 vs. general ratio 3.5/1) making us think that migration of stones is much more frequent in females. The observation that migration of stone process is more characteristic in female patients it is noticed also from the fact that cystic duct stone finding ratio ( CDS F/M 6.0/1 ) as well as Hartman's pouch stone finding ratio ( HPS F/M 6.0/1 ) overwhelmes the general F/M ratio of 3.5/1 It is interesting to mark that all gall bladder mucocoele cases (20) were females and so was for Mirizzi syndrome ( 10 cases, all females ) Over the age of 75, the chances of having an emergency intervention are higher than in general (> 75 years, Elective/Emergency ratio is 3.6/1 vs. General Elective/Emergency ratio is 5.5/1). An emergency operation lasted an average of 25 minutes more in the studied group compared with the elective one, suggesting that the emergency cholecystectomies carry a higher degree of complexity. The interventions lasted between 10 and 403 minutes, with all cases under 30 minutes (4) being female patients. Retrospective analysis of over 500 consecutive cholecystectomies that were carried out by a single surgeon over a 10 year period in a typical UK District General Hospital. Multivariable analysis was carried out for 30 distinct variables that were judged to add complexity and impact the outcome. This study confirmed the prevalence of gallstone disease in females with most patients in their 5th decade of life. The male patients developed worse presentations of disease with more gall bladder abscesses found and higher rate of perforation than the overall group ratio. In exchange, female presented in more occasions with migratory complications of the disease. Median age of operated males was 7 years more than of the females in the study, suggesting that females develop gall stone disease at younger ages. Operated cases in patients over 75 years of age showed NO significant statistical difference between males and females. With advancing age (by groups), the difference between operated females and males narrows. To study a decade worth of a typical single-surgeon’s cholecystectomy data in the hope of understanding the validity and limitations of any current suggested datasets or procedure-specific comparative tool. Publication of individual surgeons’ outcomes is hailed as a watershed moment for surgery. However, the validity and utility of such data for comparative purposes is doubtful in absence of a validated, and risk-adjusted procedure-specific dataset.