The anti ‐ hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ ‐ dependent inhibition of the AKT pathway by Suzana Assad Kahn, Silvia.

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Presentation transcript:

The anti ‐ hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ ‐ dependent inhibition of the AKT pathway by Suzana Assad Kahn, Silvia Lima Costa, Sharareh Gholamin, Ryan T Nitta, Luiz Gustavo Dubois, Marie Fève, Maria Zeniou, Paulo Lucas Cerqueira Coelho, Elias El ‐ Habr, Josette Cadusseau, Pascale Varlet, Siddhartha S Mitra, Bertrand Devaux, Marie ‐ Claude Kilhoffer, Samuel H Cheshier, Vivaldo Moura ‐ Neto, Jacques Haiech, Marie ‐ Pierre Junier, and Hervé Chneiweiss EMBO Mol Med. Volume ():e April 4, 2016 ©2016 by European Molecular Biology Organization

Prazosin inhibits GIC survival Suzana Assad Kahn et al. EMBO Mol Med. doi: /emmm ©2016 by European Molecular Biology Organization

Prazosin induces GIC apoptosis Suzana Assad Kahn et al. EMBO Mol Med. doi: /emmm ©2016 by European Molecular Biology Organization

Extreme limiting dilution assay of GBM44 Suzana Assad Kahn et al. EMBO Mol Med. doi: /emmm ©2016 by European Molecular Biology Organization

Prazosin inhibits glioblastoma growth in vivo Suzana Assad Kahn et al. EMBO Mol Med. doi: /emmm ©2016 by European Molecular Biology Organization

Prazosin inhibits glioblastoma growth in immunocompetent mice Suzana Assad Kahn et al. EMBO Mol Med. doi: /emmm ©2016 by European Molecular Biology Organization

Prazosin induces GIC apoptosis independently from α ‐ AR Suzana Assad Kahn et al. EMBO Mol Med. doi: /emmm ©2016 by European Molecular Biology Organization

Prazosin ‐ induced apoptosis is accompanied with reduced GIC proliferation Suzana Assad Kahn et al. EMBO Mol Med. doi: /emmm ©2016 by European Molecular Biology Organization

Prazosin induces GIC apoptosis in a PKCδ ‐ dependent manner Suzana Assad Kahn et al. EMBO Mol Med. doi: /emmm ©2016 by European Molecular Biology Organization

PKCδ expression and silencing in GIC and differentiated cells Suzana Assad Kahn et al. EMBO Mol Med. doi: /emmm ©2016 by European Molecular Biology Organization

Prazosin inhibits glioblastoma growth in vivo in a PKCδ ‐ dependent manner Suzana Assad Kahn et al. EMBO Mol Med. doi: /emmm ©2016 by European Molecular Biology Organization

PKCδ expression is associated with a poorer prognosis in human patients Suzana Assad Kahn et al. EMBO Mol Med. doi: /emmm ©2016 by European Molecular Biology Organization