Preeclampsia, Ig A nephropathy and Behcet disease 신장내과 R4 최선영

 Preeclampsia Syndrome of hypertension and proteinuria in last trimester Only in the presence of the placenta Remits dramatically postpartum  Severe preeclampsia Presence of systemic endothelial dysfunction and microangiopathy Target organ damage  Brain – seizure, eclampsia  Liver – HELLP syndrome  Kidney – glomerular endotheliosis and proteinuria

Renal dysfunction of preeclampsia  GFR and RPA 30-40% decrease than normal pregnancy  Proteinuria : after hypertension usually Pregnancy terminated  proteinuria disappears within 3-8 weeks Quantity of protein in the urine : <1g ~ 8-10g  Pathology : glomerular capillary endotheliosis LM : endothelial and mesangial swelling and hypertrophy EM : loss of endothelial fenetration

Obstet Gynecol 2000;96:945–9

Behçet’s disease and GN  Behçet’s disease (BD) : multisystemic vasculitis Recurrent oral ulcer, genital ulcer, uveitis  Urinary abnormality in BD patients : 7.5~32% Asymptomatic microhematuria and/or proteinuria  Renal involvement in BD Pyelonephritis, renovascular theombosis & stenosis, amyloidosis, glomerulonephritis  Pathophysiology Vasculitis, immune complex deposition Autoimmune ? ANCA ?

Clin Rheumatol (2002) 21: /4212