Connecting World Class Science to Consumer Health Founder Teresa O’KeefeCEO Tim Davenport

We Believe…  People don’t understand how healthy they are (or not)  Lab results confuse people  Doctor/patient interactions, HRAs & wellness programs aren’t providing an holistic, understandable view of health  Each of us has a unique pathway to being healthy  People desire a good quality of life as they age Consumable Science delivers world class science into the hands of consumers to help them understand and better manage their health 2

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Score Design 4 The purpose of MyBodyScore is to provide an individual a measure of their risk of natural death relative to others of the same age and gender. Biomarker Requirements  Highly predictive and relatively stable  Modifiable by behaviors: diet, exercise, tobacco use and medication adherence.  Package-able at a convenience and price point for the market  Comprehensive in that biomarkers indicate multiple body systems Biomarker Requirements  Highly predictive and relatively stable  Modifiable by behaviors: diet, exercise, tobacco use and medication adherence.  Package-able at a convenience and price point for the market  Comprehensive in that biomarkers indicate multiple body systems Disease Warning  Heart & Atherosclerosis  Lung  Kidney  Metabolic Syndrome  Diabetes Mellitus Disease Warning  Heart & Atherosclerosis  Lung  Kidney  Metabolic Syndrome  Diabetes Mellitus Note: The MBS Account, including biomarker & Score data, is portable to the Consumer. We connect Sponsors to their eligible Participant’s data as appropriate.

Epidemiology 5 MyBodyScore is based on contracted research performed by Johns Hopkins University researchers which examined the relationship of a panel of biomarker values with mortality over a long period of follow- up. A cohort was used where biomarkers and disease-related mortality has been tracked for 30,000+ U.S. residents since the 1990s. This Cox Proportional Hazards Regression analysis produces a hazard ratio, or weight, for each of the Score's 5 non-blood based inputs (height, weight, age, gender and systolic blood pressure) and 5 blood- based inputs (total cholesterol, HDL cholesterol, HbA1c, creatinine, and cotinine). This analysis is particularly important since the relationship of each biomarker with mortality is influenced by the value of other biomarkers. Therefore, the biomarkers must be included together in a single model. The hazard ratios associated with the biomarkers are combined into a single score, which is then adjusted to fit the same range as a financial credit score (300 to 850) with the median MyBodyScore at approximately 723.

Context of Score  A Score of 723 reflects average life expectancy  A Score over 800 reflects above average life expectancy  Intuitively, lower Scores reflect more risk of “health events”, a lower quality of life and higher healthcare costs as one ages Our next generation of research can focus on proving that higher Scores above 740, for example, lead to a better quality of life and lower healthcare costs. 6 The range differential at the lower half enables the less healthy to improve their Score faster and be encouraged by results of building block behavior changes.

Stratification and Benchmarking Scores can be averaged across populations 7  Stratify Your Population  Identify At-Risk Individuals  Measure Health Management ROI  Scores for Populations  Locations (Contests)  Age Groups  Dependents  Health Plans Dependents Chicago Austin

National Business Group on Health Conference October Towers Watson 2/3 desire to self-direct their health 1/3 aren’t interested, “I’m a rock climber” Culture of Health ⍯ A Healthy Culture Big Brother perception has to be carefully managed 8

How Can You Leverage MyBodyScore? 9  Would you like for your managed population to understand their health risk in a meaningful way?  Do you have a consumer portal that enables self-reported data and educational content?  Would you like to offer incentives to your population?  Do you desire to have a baseline of health for your populations?  Would you be able to use/integrate MBS population health to your health risk stratification, management and benchmarking?

User Experience In 2015, our three pilots with zero incentive had % participation 10 Testimonials