Stewart Wiseman Brain Research Imaging Centre School of Clinical Sciences PhD - 10 week review January 2013.

Slides:

Advertisements

Similar presentations

Atherosclerosis Mike Clark, M.D.. Terms Arteriosclerosis – hardening of the arteries Atherosclerosis – a form of arteriosclerosis Venosclerosis Arteriolosclerosis.

Advertisements

ATHEROMA: MORPHOLOGY and EFFECTS

Multiple Sclerosis The Malaysian Saga Dr Rahul Chavan, MD Medical Director, Malaysia.

C-Reactive Protein: New Applications Dr Job Ubbink, D.Sc (Pret), MRCPath (Lond) Consultant: Chemical Pathology.

Types of peripheral neuropathy Sensory Motor Autonomic Combined i.e. diabetic neuropathy i.e. Guillain-Barré i.e. Dysautonomia, diabetic autonomic neuropathy.

Dr Verity Blackwell West Hertfordshire Dermatology Team.

FREQUENTLY ASKED QUESTIONS. Frequently Asked Questions Why is it important to understand the mechanisms of inflammation in joint diseases? Is joint pain.

Multiple Sclerosis Definition: Multiple sclerosis (MS) is a disease of the central nervous system (CNS); it damages the protective coating around the.

Multiple Sclerosis Abdulelah Nuqali Intern. DemyelinationCNSAquired Multiple Sclerosis Optic neuritis Acute Disseminated Encephalomyelitis Hereditary.

Subtype of VaD: SIVD Subcortical Ischemic Vascular Disease Helena Chui, M.D. University of Southern California Rancho Los Amigos National Rehabilitation.

MUSCULOSKELETAL DISEASES National Healthcare Quality and Disparities Report Chartbook on Effective Treatment.

Imaging in headache patients “Incidentalomas” Giles Elrington Barts & The London

Screening for Stroke and Cognitive Impairment Chapter 2: Background.

Chapter 5 Coronary Heart Disease. P-96  CHD is usually a disease of high-income countries, but also in low and middle-income countries.  Recorded history.

Rheumatoid Arthritis of the Cervical Spine Zikou Anastasia Radiology Department University Hospital of Ioannina.

A 62-year-old man with progressive action tremor and a 74-year-old man with progressive ataxia Teaching NeuroImages Neurology Resident and Fellow Section.

Consultant Neurologist,

Atherosclerosis Hisham Al Khalidi. Vessel wall structure.

Overview of Arthritis Brought to you in collaboration by: 1. Arthritis Foundation Tennessee Chapter 2. Tennessee Department of Health 3. University of.

NA-MIC National Alliance for Medical Image Computing Lesion Classification in Lupus Update H. Jeremy Bockholt DBP2, MIND.

Multiple Sclerosis Alan Chen 4/1/14. General Information Other names: disseminated sclerosis or encephalomyelitis disseminata Inflammatory disease that.

Sagittal FLAIR images - Stable nonenhancing hyperintensities within the pericallosal white matter and bilateral centrum semiovale, consistent with known.

Cerebrovascular Disease 2/22/06 Basic Science. Which of the following contributes to ischemic strokes: 1) Embolization of atherosclerotic and thrombotic.

National Alliance for Medical Image Computing DBP: The Analysis of Brain Lesions in Neuropsychiatric Systemic Lupus Erythematosis H Jeremy.

ASSOCIATION OF CIRCULATING SERUM LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR-A WITH VASCULAR ULTRASOUND DETERMINANTS OF DEMENTIA IN PATIENTS WITH TYPE.

Atherosclerosis CVS lecture 2 Atherosclerosis Shaesta Naseem.

Atherosclerosis CVS 1 Hisham Al Khalidi. Atherosclerosis.wmv.

Phospholipids Analogs as a New Anti-Inflammatory Anti- Atherosclerosis Therapy Dror Harats The Institute of Lipids and Atherosclerosis Research, Sheba.

Atherosclerosis CVS lecture 2 Atherosclerosis. Vessel wall structure.

Faculty of allied medical sciences

Background. Vascular Cognitive Impairment Vascular Cognitive Impairment (VCI) includes the cognitive and behavioural disorders associated with cerebrovascular.

Differential Diagnoses for Quadriparesis

Normal blood vessels A= artery V= vein. ARTERIOSCLEROSIS Arteriosclerosis literally means "hardening of the arteries" It reflects arterial wall thickening.

USZ / NRA Imaging of Spinal Stroke Institute of Neuroradiology, University of Zurich, Switzerland.

The Role of MRI in Perinatal Anoxic Ischaemic Brain Injury

Magnetic Resonance Imaging In Young Patients With Neuro - Psychiatric SLE : A Case Series Dr. Vivek Gupta Department of Radiodiagnosis Postgraduate Institute.

Rheumatology What we do & How to help Ronan Mullan.

Peripheral Artery Disease in Orthopaedic Patients with Asymptomatic Popliteal Artery Calcification on Plain X-ray Adam Podet, MS; Julia Volaufova, phD,;

Cardioembolic Stroke: Diagnosis and Management

MRI neuroimaging study day Saturday 6 April 2013.

Neuroimaging Pearls For The Primary Care Provider Praveen Dayalu, MD Clinical Associate Professor Department of Neurology University of Michigan.

We analyze the neurological symptoms and provide special neurology treatment. Neurologist, Moeen Din, M.D treats stroke, headache, migraine etc.

In The Name of God. Multiple Sclerosis and Normal MRI new modalities for problems solving.

Ischaemic heart disease. Coronary artery disease(CAD) is the leading cause of death worldwide. The rates of mortality and disability due to CAD are increasing.

4. Rheumatologic conditions

Hemophilia 2009.

The role of unknown risk factors in coronary heart disease

Clinical Immunology Jasmina Makarevic

Activity Communication Breakdown

Teaching NeuroImages Neurology Resident and Fellow Section

Dr. Syed Waleem Pasha Assistant Professor Yenepoya Medical College

FRAX & ITS ASSOCIATIONS IN RHEUMATOID ARTHRITIS

Cerebrovasc Dis 2014;37: DOI: /

Authors: Prof. Joanna Wardlaw & Dr. Karen Ferguson

Figure 1 Perivenous distribution of multiple sclerosis lesions

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and Review of Literature Zebin Xiao Department of.

Setareh Omran, MD Vascular Neurology Fellow

Normal blood vessels A= artery V= vein.

Nat. Rev. Neurol. doi: /nrneurol

Example of MRIs of a lacune from a haemorrhagic source (A,B), and from a lacunar infarct (C, D). Example of MRIs of a lacune from a haemorrhagic source.

A 21 year old woman with frequent vomiting

Long-term appearances of lacunar infarcts (arrows: old stroke lesion on the follow-up scans). Long-term appearances of lacunar infarcts (arrows: old stroke.

Example of MRIs of a lacune from a haemorrhagic source (A,B), and from a lacunar infarct (C, D). Example of MRIs of a lacune from a haemorrhagic source.

CBD Oil for Chronic Pain Researchers in the same report also note that there is substantial evidence that CBD oil is an.

A, Baseline MR imaging study (transverse fast FLAIR T2-weighted image) of a 56-year-old patient with hepatitis C cirrhosis without overt hepatic encephalopathy.

Long-term appearances of lacunar infarcts (arrows: old stroke lesion on the follow-up scans). Long-term appearances of lacunar infarcts (arrows: old stroke.

T2-weighted (A), FLAIR (B), and isotropic DWI (C) of a unilateral lesion in a patient with an acute or chronic presentation of worsening right-sided weakness.

Sample MR images obtained acutely from patients 1 to 6: axial T2 weighted (DWI in case 4) on the left, coronal FLAIR on the right of each panel. Sample.

A–D, Multiple tiny cortico-subcortical lesions in the right motor region on DWI (approximately 1500/115/18; 2 RR intervals) study (A) confirm the ischemic.

Atrophied Brain T2 Lesion Volume at MRI Is Associated with Disability Progression and Conversion to Secondary Progressive Multiple Sclerosis The rate.

Presentation transcript:

Stewart Wiseman Brain Research Imaging Centre School of Clinical Sciences PhD - 10 week review January 2013

Radiographer Interested in research, research methods, statistics Interested in imaging, chronic inflammatory arthritis and autoimmunity About me BRIC scanner (1.5T GE Signa HDx)

Location

Overview CSVD Acute lacunar infarct on DWI WMH on FLAIR Cause unknown Role for inflammation? Endothelial dysfunction…* Not large artery atheromatus (but atheroma might be involved, and atherosclerotic disease itself is considered an inflammatory process) * is evident in lacunar stroke versus normal, as measured by vascular response to hypercapnia or infusion of L-arginine. Stevenson et al Rheumatic diseases Measureable components Specific diagnoses Inflammatory markers DAS Pain rating Range of joint mobility & muscle weakness - Experts in inflammation Imaging Measureable components White matter hyperintensities Acute lacunar infarcts Lacunes EPVS BMBs - Experts in imaging

Related areas (but not our main focus) Inflammatory diseases of the CNS Multiple Sclerosis Neurological complications of rheumatic disease Cord compression Nerve root compression Spontaneous dislocation / subluxation Psychological (eg, in lupus) RA to controls n=11,633 followed over 5 years Incidence of stroke 7 per 1,000 patient years RR 1.4 (95%CI 1.3 to 1.5) Watson et al. J Rheumatol 2003;30:1196–202 Large artery atheromatous and cardioembolic stroke Associations with rheumatic diseases (eg, higher mortality in RA largely attributed to atherosclerosis; increased plaque burden in lupus)

Background reading Learning about and how to do systematic reviews Attended GCP Currently completing a systematic review started in 2009 Started to learn image processing techniques (including use of software tools developed at our Centre) What I have done so far

Plasma and serum markers of coagulation, fibrinolysis, endothelial activation and inflammation in lacunar stroke versus other stroke subtypes and non-stroke controls Systematic Review 12 different markers 43 included papers Hopefully Cochrane quality (but not Cochrane registered)

Systematic Review Markerfor tPAThrombus / coagulation vWFEndothelial damage ICAMInflammation / endothelial activation VCAMInflammation / endothelial activation PAIThrombus / coagulation E-SelectinInflammation / endothelial activation P-SelectinInflammation / endothelial activation FibrinogenClotting / inflammation CRPInflammation HomocysteineInflammation / endothelial activation D-dimerFibrinolysis IL-6Inflammation

Plans for remainder of first year Finish segmenting white matter lesions on Edinburgh Stroke Study Finish systematic review of plasma markers in stroke subtypes Continue reading * Literature review – specific rheumatic diseases and stroke in general Systematic review – TNF-α in ischaemic stroke subtypes Get to grips with data (imaging and inflammatory) held on four studies (Edinburgh Stroke Study, Mild Stroke Study I, Mild Stroke Study II, LBC 1936) Perform analyses thereon Tutoring on our online Masters in neuroimaging Start to plan for a small imaging study on lupus patients * Discussion today would be helpful January Feb - Sept