0 10 20 30 40 50 60 70 80 90 100 013 5 SA-β-Gal positivity (%) Days after 6 Gy of IR exposure 3 Morphology SA-  -Gal 015 Supplementary Fig. S1 A B.

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SA-β-Gal positivity (%) Days after 6 Gy of IR exposure 3 Morphology SA-  -Gal 015 Supplementary Fig. S1 A B

Supplementary Fig. S Sene pI310 pI310 M.W. (kDa) 70− 50− 30− 20− 10− 100− 200− Prol

Supplementary Fig. S3 ProlSene Serum-free media ProlSene Complete media Dead cells (%) Serum-free media Complete media Actin c-PARP p21 ProlSeneProlSene PC Serum-free media Complete media A BC

(ng/ml) hRKIP Inactivated hRKIP Supplementary Fig. S4