8.3 DNA Replication Keystone Review: Lipids + lipase  fatty acids + lipase Lipids + amylase  lipids + amylase What do the reactions above indicate about enzyme behavior? A) enzymes lower activation energy B) enzymes reduce chemical reaction rates C) enzymes have specific relationships with substrates D) enzymes maintain homeostasis

8.3 DNA Replication Updates: 5.1 DRTA/power notes due Homework: –Quizzes postponed resume Monday: 5.1 –8.3 power notes/reinforcement due Monday AAP: Tuesday and Thursday Reschedule tests ASAP! Last call for unit 5 absent work Monday!

8.3 DNA Replication LEQ: How is DNA copied during cell division? Activator: Collins Writing I 3 lines (or more): What is the most important thing to remember about _______ when it comes to DNA? –Structure/function –Base pairs –DNA as a template Key Terms – DNA replication

8.3 DNA Replication Howard and Pelc demonstrated cell division in bodies The cell cycle is a regular pattern of growth and division displayed by many cells.

8.3 DNA Replication Gap 1 (G 1 ): growth, increases organelles, proteins –varies the most

8.3 DNA Replication DNA synthesis (S): DNA replication

8.3 DNA Replication DNA replication produces more DNA for cell division. DNA replication copies the genetic information of every DNA molecule in a cell during cell division.

8.3 DNA Replication The original cell DNA serves as a template for replication. 1) the enzyme helicase, separate strands of the double helix. –Bases can be read as a template nucleotide The DNA molecule unzips in both directions.

8.3 DNA Replication 2) DNA polymerase enzymes covalently bond the nucleotides together to form a new strand. DNA polymerase new strand nucleotide

8.3 DNA Replication DNA replication is semi-conservative: –New molecule includes old strand and new strand –Conserves genetic information for “daughter” cells original strand new strand Two molecules of DNA

8.3 DNA Replication Replication Frayer divide an area into four quadrants –Definition: define the term –Key facts: summarize the process –Real life examples: when, where, who? –Non-examples: what central dogma processes and cell cycle stages do not involve replication?

8.3 DNA Replication Mutations accumulate during DNA replication Proofreading mechanisms do not correct all errors…

8.3 DNA Replication Strands are proof-read, but mutations do occur

8.3 DNA Replication

Overview: How DNA Replicates What is the shape and what are the building blocks of the DNA molecule? Which DNA bases pair with each other? What part of the DNA molecule do they form?

8.3 DNA Replication Summary Questions: What is replication? Why is replication significant in explaining heredity? What is the function of DNA polymerase? Explain how a DNA molecule contains the information necessary to produce copies of itself.