ACRIN EISC Experimental Imaging Sciences Committee (EISC) David Mankoff, MD, PhD Experimental Imaging Sciences Committee Chair Professor of Radiology University of Washington Seattle Cancer Care Alliance Seattle, Washington

ACRIN EISC Questions for Panel What logistical issues have you run into in the distribution of IND- based PET agents for clinical trials? (ACRIN and others) – Production issues? – Regulatory, QC, etc? – Financial issues? What do you see as the pathway for developing and testing new compounds for PET imaging? – Non-proprietary compounds (e.g., FLT, FMISO, FES) – Proprietary compounds – Industry vs cooperative group/NCI trials? How do you decide whether to bring a new compound into commercial production? What new compounds do you see on the horizon?

ACRIN EISC David Mankoff, MD, PhD Experimental Imaging Sciences Committee Chair Professor of Radiology University of Washington Seattle Cancer Care Alliance Seattle, Washington Experimental Imaging Sciences Committee (EISC)