CD8 + T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia by Li Ma, Elisa Simpson,

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CD8 + T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia by Li Ma, Elisa Simpson, June Li, Min Xuan, Miao Xu, Laura Baker, Yan Shi, Issaka Yougbaré, Xiaozhong Wang, Guangheng Zhu, Pingguo Chen, Gerald J. Prud’homme, Alan H. Lazarus, John Freedman, and Heyu Ni Blood Volume 126(2): July 9, 2015 ©2015 by American Society of Hematology

Establishment of murine models of steroid therapy in ITP. (A) The passive model of ITP was generated by injecting anti-β3 integrin polysera or mAbs (9D2, PSI C1, or JAN C1) into WT BALB/c mice. Li Ma et al. Blood 2015;126: ©2015 by American Society of Hematology

Depletion of CD8+ T cells results in more severe thrombocytopenia and impairs responsiveness to steroid therapy in vivo. Li Ma et al. Blood 2015;126: ©2015 by American Society of Hematology

CD8+ T-cell transfusion therapeutically attenuated platelet clearance and enhanced response to DEX in passive murine model of ITP. In the passive model of ITP, mice were injected with anti-β3 integrin mAb (9D2, 1 μg, intraperitoneally) at day 0 and transfus... Li Ma et al. Blood 2015;126: ©2015 by American Society of Hematology

Steroid treatment selectively increased CD8+ Tregs in both the passive and active models of ITP. (A) In the passive model of ITP, mice were injected with anti-β3 mAb (9D2, 1 μg, intraperitoneally) at day 0. Li Ma et al. Blood 2015;126: ©2015 by American Society of Hematology

CD8+ T cells suppressed platelet apoptosis and clearance in vitro. Li Ma et al. Blood 2015;126: ©2015 by American Society of Hematology

CD8+ Tregs from immunized β3−/− mice inhibit the adaptive antiplatelet immune response in vitro. Li Ma et al. Blood 2015;126: ©2015 by American Society of Hematology

CD8+ Tregs from immunized β3−/− mice inhibit CD8+ cytotoxic activity against platelets. Li Ma et al. Blood 2015;126: ©2015 by American Society of Hematology