Hematopoietic Cancers Common Disruptions 1

2

3

Burkitt’s Lymphoma 4

5

6 Endemic Lymphoma (comorbid with Malaria & EBV infection)

Epstein-Barr Virus (EBV)? Avian Myelocytomatosis Virus 7

8

9

10

11

N--C 12

bHLH E-box: CACGTG 13

14

15

16

17

18

19

cyclin D + CDK4 20

21

22

23

24

25

ALL 26

Delta/Jagged Growth promoting gene transcription 27

Growth promoting gene transcription Extracellular 28

29

CML 30

31

32

33

34

35

36

37 ADPAmino acid (tyr) side chain

38

39

40

41 Imatinib

42

43

44

45

46

47

48

49

50

51

52 Tumor regression Tumor relapse

53

54

CML 55 APL

56 Clinical and Molecular Features: Severe bleeding tendency Promyelocytes in peripheral blood and bone marrow Chromosomal translocation between 17q21 and (often) 15q22 Fusion transcripts: PML-RAR 

57

58 differentiation genes

59 ATRA

60

Hodgkin’s Lymphoma 61

62 Reed–Sternberg cells

63

64 Target Genes of NF-kB Cytokines/Chemokines and their Modulators Immunoreceptors Proteins Involved in Antigen Presentation Cell Adhesion Molecules Acute Phase Proteins Stress Response Genes Cell Surface Receptors Regulators of Apoptosis Growth Factors, Ligands and their Modulators Early Response Genes Transcription Factors Enzymes

AML 65

66

c-Kit 67

68

FLT3 69

70