LS96 (working name) Confidential information

Content Idea Configuration Technical Data USPs / Benefits Application Project Roadmap

Requirements of the new Life Science markets Small benchtop devices Low-priced Simple and intuitive operating without intensive training Design-orientated devices Low throughput Independent on application Plug & play Idea That was the birth of the LS96

LS96 – The new generation of simple pipetting Combination of CyBio’s core know how  Liquid handling + The simple and effective handling of pipettes + Life style Idea = The modern semi-automated 96-fold pipettor

Idea – Device concept  Semi-automated pipettor  motors for error-prone processes  2 operation levels  Touch screen  bottoms for pipetting and z- movement  Easy to use without Computer  no programming necessary  Simple and fast tip changing  proven tip sealing technique from the HTS  high precision and robustness  Memory function  for saving pipetting parameters and heights

Configuration 1: 96 channels, µl Configuration 2: 96 channels, µl Accessories: Different trays  for 96- well microplates  for 384- well microplates  with different numbers of working positions  special TipTray for serial dilutions  autoclavable trays ... Consumables: CyBio tips in TipTrays and as bulk ware Configuration

Channel96 + option for 8 channel via special TipTray Volume Range250: 5 µl – 250 µl 25: 0.5 µl – 25 µl Disposable Tip Size25 µL, 250 µL Precision Specification250: 5 – 25 µl ≤ 2%; 25 – 250 µl ≤ 1% 25: 0.5 – 2 µL ≤ 3%; 2 – 5 µl ≤ 2%; 5 – 25 µl ≤ 1%; Plate FormatsShallow-Well and Deep-Well plates: 96, 384 Plate Positions2 Dimentions w/ h/ d (mm)307 x 480 x 325 WeightApprox. 15 kg Operating Conditions15 °C to 35 °C; humidity < 85% at 30 °C Technical Data Technical Data not released yet  final tests have to be performed

Possible customers are: All groups...  working in microplate formats  working with manual or electrical pipettes  needing a device for simple experiments  needing precise and accurate results  needing a high reproducibility (no human errors or differences)  having a low or medium budget  making low throughput Target groups

USPs  Easy and fast tip changing  High throughput proven tip sealing principle  Semi-automated device  automated vertical drive of the head  eliminate errors during pipetting process  Reminder function (save of parameters like heights  processing of more plates (e.g. 10 plates in rapid succession)  Movement of the head (z-direction) and the open design allow the use of external devices like Shaker, vacuum chamber, heating adapters and so on USPs / Benefits

Benefits  A device for everyone (no technical or programming background necessary)  Eliminate human errors  always reproducible results  Ease of operation with a display  no programming knowledge and computer necessary  Easy and fast pipetting of microplates  Operation is similar to pipettes  Plug & play - easy to install no service and training for the set-up required  Small footprint – benchtop device – fit into laminar flow boxes  Low budget device  Adaptive of a wide range of applications USPs / Benefits

The device is free for any applications All application in 96- or 384-well microplates can be handled and processed Application could be:  Replication  Reformatting  Adding of medium (cell biology)  ELISA  Reagent adding  Plate cleaning and emptying  Plate coating  Dilution, serial dilution Application fields could be:  Biology  Biochemistry  Molecular biology  Immunology  Microbiology  Chemistry Application

Project roadmap AugSep OctNov DecJanFebMarch Development Presentation BioTechnica Launch MipTec Acquisition Release Sale 06. – – April Test and revision First introduction for our distributors