Ophthalmic Dose Compliace Monitor

Our Team Benjamin Roedl – Team Leader Benjamin Roedl – Team Leader Nina Lewis – Team Leader Nina Lewis – Team Leader Ashley Phillips – BWIG Ashley Phillips – BWIG Patrick Schenk – Communications Patrick Schenk – Communications Brett Mulawka – BSAC Brett Mulawka – BSAC

Client & Advisor Advisor: William Murphy, Professor of Biomedical Engineering Advisor: William Murphy, Professor of Biomedical Engineering Client: Christopher J. Murphy, DVM, PhD Client: Christopher J. Murphy, DVM, PhD

Problem Statement Miniaturize and discretely place the previously designed device that will record the date and time of each administered dose of ophthalmic medication unbeknownst to the user.

Motivation Pet owners will be monitored in order to see how compliant they are with doctor’s orders. Depending on the outcome of the study, doctors may alter their treatment plan.

Background Design Components Design Components Hall Sensor & Magnet Hall Sensor & Magnet Tilt Sensor Tilt Sensor Microprocessor Microprocessor Circuit Circuit

Microproccesor PIC 16F688 I/P PIC 16F688 I/P Interfaces the signals from the hall sensor and the tilt sensor Interfaces the signals from the hall sensor and the tilt sensor Records and stores data Records and stores data 256 byte EEPROM memory 256 byte EEPROM memory Schematic 1

Magnetic Sensor A3211 magnetic field sensor A3211 magnetic field sensor Circuit switches close in the presence of a magnetic field Circuit switches close in the presence of a magnetic field Typically around 37 Gauss Typically around 37 Gauss Circuit switches open without magnetic field Circuit switches open without magnetic field Produce output voltage of 5 V when in mag. field Produce output voltage of 5 V when in mag. field Figure 1. Hall Sensor (3)

Magnetic Sensor Specifics Small magnet attached to exterior of bottle’s cap Small magnet attached to exterior of bottle’s cap Sensor located below cap, attached to outer surface of bottle Sensor located below cap, attached to outer surface of bottle Current magnet needs to be approximately 1 cm away from censor to register an open cap Current magnet needs to be approximately 1 cm away from censor to register an open cap We plan on ordering a Baferrite Srferrite magnet We plan on ordering a Baferrite Srferrite magnet Strength : approximately Gauss Strength : approximately Gauss

Client Requirements Our device must: Record the date and time of each administered dose Record the date and time of each administered dose The device must be small enough to discretely fit on the outside of an eye drop bottle The device must be small enough to discretely fit on the outside of an eye drop bottle Device cannot compromise the sterility of the medication Device cannot compromise the sterility of the medication Data must be transferred from the device to a computer Data must be transferred from the device to a computer Cost around $100/bottle Cost around $100/bottle

Data Transfer Options Serial Cable Serial Cable Direct connection to the circuit Direct connection to the circuit RFID RFID Active or Passive Active or Passive Memory Storage available Memory Storage available Free-Space Optical Transmission Free-Space Optical Transmission Utilizes a LED light Utilizes a LED light

Data Transfer Option 1: Serial Cable 9-pin serial port 9-pin serial port 1 of 9 pins receives data 1 of 9 pins receives data 1 of 9 pins transmits data 1 of 9 pins transmits data Speed: 1,920 bytes/sec to 11,520 bytes/sec Speed: 1,920 bytes/sec to 11,520 bytes/sec Pros: Fast transfer Previously implemented Cheap ($10, one time cost) Cons: User must plug leads into miniaturized circuit Figure 2. Serial Port (1)

Data Transfer Option 2: RFID Radio Frequency Identification Radio Frequency Identification Active and Passive Tags Active and Passive Tags Pros: Small (.25 mm x.25 mm) Cheap ($0.07/RFID; reader starting at $40, one time cost) No wire connections Cons: Must be integrated into the circuit Figure 3. RFID (6)

Data Transfer Option 3: Optics Flashing LED symbolizes digital information Flashing LED symbolizes digital information Currently used in long distance transfers Currently used in long distance transfers Pros: Fast (10 Mbytes/sec) Can read data from 0 to 100 cm Inexpensive ($0.20 – LED; $90 – IR 220LR, one time cost) No Wire Connections Cons: Needs convenient, discrete placement on circuit Must be integrated into circuit Figure 4. Optical Receiver (5)

Decision Matrix RFIDOptics Serial Cable Cost555 Ease of Use 541 Transfer Speed 555 Difficulty435 Size535 Total242021

Future Work Continue testing circuit Continue testing circuit Order new circuit components Order new circuit components Order sleeve Order sleeve RFID for wireless data transfer RFID for wireless data transfer Miniaturize circuit through ExpressPCB Miniaturize circuit through ExpressPCB Contact Companies Contact Companies Surface Mounting Surface Mounting Deliver 10 working bottles Deliver 10 working bottles

Any Questions?

Resources Cell080809L_NVSRAM.pdf Cell080809L_NVSRAM.pdfhttp:// Cell080809L_NVSRAM.pdf ID= ID=1106http:// ID=1106

Power Source Surface mount rechargeable battery Surface mount rechargeable battery Power Fab CPF L Power Fab CPF L Output voltage : 3.8V Output voltage : 3.8V Size : 8mm x 8mm x 0.9 mm Size : 8mm x 8mm x 0.9 mm Chosen because exceptionally thin Chosen because exceptionally thin Recharge time : 20 min. (75%) Recharge time : 20 min. (75%)

Sleeve Options Neoprene material Neoprene material Thin tubing much like a can cooler placed over the circuit components Thin tubing much like a can cooler placed over the circuit components Apply medication label over the neoprene Apply medication label over the neoprene Shrink sleeve Place thin film plastic over bottle Apply heat and have the plastic form around the circuit and sensor Apply medication label over the shrink sleeve