Date of download: 6/23/2016 From: The Anticipated Clinical and Economic Effects of 90–90–90 in South Africa Ann Intern Med. Published online May 31, 2016.

Slides:



Advertisements
Similar presentations
Retention across the continuum of care in a cohort of HIV infected children in rural India G. Alvarez-Uria RDT Hospital, Department of Infectious Diseases,
Advertisements

HIV/AIDS is threatening Africa beyond the scope of Health.
Date of download: 5/27/2016 From: Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review for a National Institutes of Health.
Date of download: 5/28/2016 From: Association Between Exposure to Low to Moderate Arsenic Levels and Incident Cardiovascular Disease: A Prospective Cohort.
Date of download: 5/28/2016 From: When to Start Antiretroviral Therapy in Resource-Limited Settings Ann Intern Med. 2009;151(3): doi: /
Date of download: 5/28/2016 From: Medicare Chronic Care Management Payments and Financial Returns to Primary Care Practices: A Modeling Study Ann Intern.
Date of download: 5/29/2016 From: A Cost Analysis of Alternative Treatments for Duodenal Ulcer Ann Intern Med. 1995;123(9): doi: /
Date of download: 5/29/2016 From: The Effect of a Lower Target Blood Pressure on the Progression of Kidney Disease: Long-Term Follow- up of the Modification.
Date of download: 5/31/2016 From: Cost-Effectiveness of HIV Screening in Patients Older than 55 Years of Age Ann Intern Med. 2008;148(12): doi: /
Date of download: 5/31/2016 From: Benefits, Harms, and Cost-Effectiveness of Supplemental Ultrasonography Screening for Women With Dense Breasts Ann Intern.
Date of download: 6/1/2016 From: Cost-Effectiveness of Radiofrequency Ablation for Supraventricular Tachycardia Ann Intern Med. 2000;133(11): doi: /
Date of download: 6/1/2016 From: Prevention of Hepatitis C by Screening and Treatment in U.S. Prisons Ann Intern Med. 2016;164(2): doi: /M
Date of download: 6/2/2016 From: Quantitative Synthesis in Systematic Reviews Ann Intern Med. 1997;127(9): doi: /
Date of download: 6/2/2016 From: Screening for Vitamin D Deficiency: A Systematic Review for the U.S. Preventive Services Task Force Ann Intern Med. 2015;162(2):
Date of download: 6/2/2016 From: Internet-Based Self-management Plus Education Compared With Usual Care in Asthma: A Randomized Trial Ann Intern Med. 2009;151(2):
Date of download: 6/3/2016 From: Sex, Age, and Birth Cohort Effects in Colorectal Neoplasms: A Cohort Analysis Ann Intern Med. 2010;152(11): doi: /
Date of download: 6/3/2016 From: Surgery Versus Nonsurgical Treatment of Lumbar Spinal Stenosis: A Randomized Trial Ann Intern Med. 2015;162(7):
Date of download: 6/3/2016 From: Elevated Plasma Homocysteine Level Is an Independent Predictor of Coronary Heart Disease Events in Patients with Type.
Date of download: 6/3/2016 From: Increased Incidence of Aortic Aneurysm and Dissection in Giant Cell (Temporal) Arteritis: A Population- Based Study Ann.
Date of download: 6/9/2016 From: Addressing Infection Prevention and Control in the First U.S. Community Hospital to Care for Patients With Ebola Virus.
Date of download: 6/21/2016 From: Psychological and Behavioral Interventions for Managing Insomnia Disorder: An Evidence Report for a Clinical Practice.
Date of download: 6/21/2016 From: The Epidemiology of Prescriptions Abandoned at the Pharmacy Ann Intern Med. 2010;153(10): doi: /
Date of download: 6/22/2016 From: Biomarkers of Inflammation and Thrombosis as Predictors of Near-Term Mortality in Patients with Peripheral Arterial Disease:
Date of download: 6/24/2016 From: Effectiveness of Manual Physical Therapy and Exercise in Osteoarthritis of the Knee: A Randomized, Controlled Trial Ann.
Date of download: 6/25/2016 From: Interferon Therapy Reduces the Risk for Hepatocellular Carcinoma: National Surveillance Program of Cirrhotic and Noncirrhotic.
Date of download: 6/25/2016 From: Cognitive Behavioral Therapy for Chronic Insomnia: A Systematic Review and Meta-analysis Ann Intern Med. 2015;163(3):
Date of download: 6/25/2016 From: Cost-Effectiveness of the Children's Oncology Group Long-Term Follow-up Screening Guidelines for Childhood Cancer Survivors.
Date of download: 6/26/2016 From: Cost-Effectiveness of Adding Cardiac Resynchronization Therapy to an Implantable Cardioverter- Defibrillator Among Patients.
Date of download: 6/26/2016 From: Variation in Outpatient Antibiotic Prescribing for Acute Respiratory Infections in the Veteran Population: A Cross-sectional.
Date of download: 6/27/2016 From: Influence of Alternative Thresholds for Initiating HIV Treatment on Quality-Adjusted Life Expectancy: A Decision Model.
Date of download: 7/2/2016 From: Recovery Rate and Prognosis in Older Persons Who Develop Acute Lung Injury and the Acute Respiratory Distress Syndrome.
Date of download: 7/6/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of Antiretroviral Therapy on Viral Load, CD4.
Date of download: 7/6/2016 From: Can Inexpensive Signs Encourage the Use of Stairs? Results from a Community Intervention Ann Intern Med. 1998;129(5):
Date of download: 7/7/2016 From: Early Coverage, Access, Utilization, and Health Effects Associated With the Affordable Care Act Medicaid Expansions: A.
Date of download: 7/8/2016 From: Economic Outcomes With Anatomical Versus Functional Diagnostic Testing for Coronary Artery Disease Ann Intern Med. Published.
Date of download: 7/8/2016 From: Did Medicare Part D Affect National Trends in Health Outcomes or Hospitalizations?: A Time-Series Analysis Ann Intern.
Date of download: 7/10/2016 From: Potential Cost-Effectiveness of Prophylactic Use of the Implantable Cardioverter Defibrillator or Amiodarone after Myocardial.
Date of download: 7/10/2016 From: Four-Week Direct-Acting Antiviral Regimens in Noncirrhotic Patients With Hepatitis C Virus Genotype 1 Infection: An Open-Label,
Date of download: 7/10/2016 From: Effect of a Culture-Based Screening Algorithm on Tuberculosis Incidence in Immigrants and Refugees Bound for the United.
Date of download: 7/11/2016 From: Safety of Herpes Zoster Vaccine in the Shingles Prevention Study: A Randomized Trial Ann Intern Med. 2010;152(9):
Date of download: 9/16/2016 From: Fluorouracil plus Levamisole as Effective Adjuvant Therapy after Resection of Stage III Colon Carcinoma: A Final Report.
Date of download: 9/17/2016 From: The Changing Burden of Hepatitis C Virus Infection in the United States: Model-Based Predictions Ann Intern Med. 2014;161(3):
Date of download: 9/17/2016 From: Topical Treatment of Pressure Ulcers with Nerve Growth Factor: A Randomized Clinical Trial Ann Intern Med. 2003;139(8):
Date of download: 9/17/2016 From: Polymerase Chain Reaction for the Diagnosis of HIV Infection in Adults: A Meta-Analysis with Recommendations for Clinical.
Date of download: 9/18/2016 From: Primary Treatment of Acquired Aplastic Anemia: Outcomes with Bone Marrow Transplantation and Immunosuppressive Therapy.
Date of download: 9/18/2016 From: “Nonfunctional” Adrenal Tumors and the Risk for Incident Diabetes and Cardiovascular Outcomes: A Cohort Study Ann Intern.
Date of download: 9/19/2016 From: The Implications of Regional Variations in Medicare Spending. Part 2: Health Outcomes and Satisfaction with Care Ann.
From: Screening for Syphilis Infection in Pregnancy: U. S
From: Two Ways of Knowing: Big Data and Evidence-Based Medicine
Ann Intern Med. 2016;165(7): doi: /M Figure Legend:
From: Cost-Effectiveness of Genotype-Guided and Dual Antiplatelet Therapies in Acute Coronary Syndrome Ann Intern Med. 2014;160(4): doi: /M
From: Effects of Low-Carbohydrate and Low-Fat DietsA Randomized Trial
Ann Intern Med. 2016;164(8): doi: /M Figure Legend:
From: Cost-Effectiveness of HIV Preexposure Prophylaxis for People Who Inject Drugs in the United States Ann Intern Med. 2016;165(1): doi: /M
From: Nonpharmacologic Versus Pharmacologic Treatment of Adult Patients With Major Depressive Disorder: A Clinical Practice Guideline From the American.
Ann Intern Med. 2014;160(11): doi: /M Figure Legend:
From: Wells Rule and d-Dimer Testing to Rule Out Pulmonary EmbolismA Systematic Review and Individual-Patient Data Meta-analysis Ann Intern Med. 2016;165(4):
Ann Intern Med. 1999;130(6): doi: / Figure Legend:
From: Systematic Review: Strategies for Using Exercise Therapy To Improve Outcomes in Chronic Low Back Pain Ann Intern Med. 2005;142(9): doi: /
From: The Evolving Diabetes Burden in the United States
From: Synopsis of the 2017 U. S. Department of Veterans Affairs/U. S
From: Economic Savings Versus Health Losses: The Cost-Effectiveness of Generic Antiretroviral Therapy in the United States Ann Intern Med. 2013;158(2):84-92.
From: Use of Decision Models in the Development of Evidence-Based Clinical Preventive Services Recommendations: Methods of the U.S. Preventive Services.
Ann Intern Med. 2014;160(9): doi: /M Figure Legend:
From: Screening for Lung Cancer With Low-Dose Computed Tomography: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation.
From: Supplemental Screening for Breast Cancer in Women With Dense Breasts: A Systematic Review for the U.S. Preventive Services Task Force Ann Intern.
From: Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology/American.
From: Low-Molecular-Weight Heparins Compared with Unfractionated Heparin for Treatment of Acute Deep Venous Thrombosis: A Cost-Effectiveness Analysis Ann.
From: Clinic-Based Treatment of Opioid-Dependent HIV-Infected Patients Versus Referral to an Opioid Treatment ProgramA Randomized Trial Ann Intern Med.
HIV Treatment: What Can You Do to Get and Keep Patients in Care?
Presentation transcript:

Date of download: 6/23/2016 From: The Anticipated Clinical and Economic Effects of 90–90–90 in South Africa Ann Intern Med. Published online May 31, doi: /M Results of the HIV treatment cascade over time, by cascade strategy. For the current pace strategy, the literature-derived data and the model-projected effects on the current South African cascade after 1, 5, and 10 y of the current pace strategy are shown. At 10 y of the current pace strategy, 44% of living patients have virologic suppression. For the UNAIDS target strategy, model output demonstrates results that might be achieved in 5 and 10 y, compared with the 90–90–90 benchmark. When screening, linkage, and adherence and retention variables of the model were adjusted to force the 5-y values to reach 90–90–90 target values, 80% of patients who were alive and had virologic suppression in 10 y. The absolute number of patients alive in the 2 strategies over time differs owing to an increased number of transmissions and deaths in the current pace strategy. ART = antiretroviral therapy; UNAIDS = Joint United Nations Programme on HIV/AIDS. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/23/2016 From: The Anticipated Clinical and Economic Effects of 90–90–90 in South Africa Ann Intern Med. Published online May 31, doi: /M Survival outcomes over time, by cascade strategy. The difference in the height of the bars in each year indicates the cumulative number of additional transmissions in the current pace strategy compared with the UNAIDS target strategy. ART = antiretroviral therapy; UNAIDS = Joint United Nations Programme on HIV/AIDS. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/23/2016 From: The Anticipated Clinical and Economic Effects of 90–90–90 in South Africa Ann Intern Med. Published online May 31, doi: /M Cumulative HIV transmissions over the 10-year model horizon. By the end of 2025, the UNAIDS target strategy results in million fewer transmission events. UNAIDS = Joint United Nations Programme on HIV/AIDS. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/23/2016 From: The Anticipated Clinical and Economic Effects of 90–90–90 in South Africa Ann Intern Med. Published online May 31, doi: /M Outcomes related to maternal orphans, by cascade strategy. “Maternal orphans” were defined as children younger than 18 years whose mother died of HIV/AIDS. Cumulative orphans are the cumulative number of children ever orphaned by HIV/AIDS during the time horizon of the analysis (see the Methods section). Current orphans are the projected number of orphans in a given year, accounting for both death among orphans after orphanhood and for aging out of being considered an orphan. The kinks in the solid lines around year 8 demonstrate the aging out of a large majority of prevalent orphans aged 9 to 14 y at model initiation. UNAIDS = Joint United Nations Programme on HIV/AIDS. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Date of download: 6/23/2016 From: The Anticipated Clinical and Economic Effects of 90–90–90 in South Africa Ann Intern Med. Published online May 31, doi: /M Results of the HIV treatment cascade over time, by cascade strategy; sensitivity analysis of an alternative way of reaching virologic suppression goals for the UNAIDS target strategy. For the current pace strategy, the literature-derived data and the model-projected effects on the current South African cascade after 1, 5, and 10 y are shown. At 10 y of the current pace strategy, 44% of living patients have virologic suppression. For the UNAIDS target strategy, model output demonstrates results that might be achieved in 5 and 10 y, compared with the 90–90–90 benchmark. In the alternative UNAIDS target strategy, lower testing and linkage rates and higher rates of virologic suppression than in the UNAIDS target strategy base case were used to achieve viral suppression goals, but less than 81% of persons on ART. Although the UNAIDS target strategy and the alternative UNAIDS target strategy have similar viral suppression rates (~73% at 5 y), they differ in the proportion of persons receiving ART (81% and 75%, respectively). The number of patients alive in the 3 strategies over time differs owing to an increased number of transmissions and deaths. ART = antiretroviral therapy; UNAIDS = Joint United Nations Programme on HIV/AIDS. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians