Pregnancy associated breast cancer (PABC)

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Presentation transcript:

Pregnancy associated breast cancer (PABC) Lilla Madaras 2nd Department of Pathology Semmelweis University Budapest, Hungary 4th Pannonia Congress of Pathology, Osijek, Croatia May 12-14 2016

Definition Breast cancer during pregnancy or within a year after its cessation

Incidence 0,6% of breast cancer cases are pregnancy related 1/10 000-1/3000 pregnancies Incidence of PABC increasing since women tend to postpone childbearing to later age

Major clinical issues Rare disease, complex situation- not enough experience with treatment of PABC Delayed diagnosis? Imaging difficult- young, dense breast altered by pregnancy related hormonal changes Treatment may potentially harm the fetus Induced abortion, preterm delivery

Disease biology Pathological features of PABC don't differ significantly from that of early-onset non-PABC Mainly TNBC and LuminalB tumors Role of tumor microenvironment

Treatment Treatment during the second and third trimester Current treatment principle is to treat patients with PABC as close to non-PABC patients as possible Pregnancy is considered as of high risk- regular fetal monitoring Long term follow up of individuals with prenatal chemotherapy

Prognosis Conflicting data about prognosis Worse outcome (compared to that of young women with non-PABC) according to some studies