Strathclyde’s natural products and assay facilities SIDR

Finding the hits you need for successful drug discovery and consumer health projects Strathclyde’s natural products and assay facilities SIDR

What you get powerful chemical library flexible facilities experienced and friendly team

Success in drug discovery is not dependent on –size of the screening collection –ultra-high throughput assays

Success in drug discovery does need –assay that is relevant to the end purpose –highly diverse chemistry set

Highly diverse chemistry set a)combichem b) natural products c) drugs

Origin of drugs : 1184 FDA-approved NCEs % total

Strathclyde’s resource

A drug discovery resource that is better than the competition’s

more biodiversity = more chemical diversity

A drug discovery resource that is better than the competition’s more biodiversity = more chemical diversity Scotland is not one of the world’s biodiversity hotspots

A drug discovery resource that is better than the competition’s more biodiversity = more chemical diversity –worldwide network –genetic diversity

SIDR’s Natural Product Network Uzbekistan Nigeria Argentina Chile Sudan Kenya Sri Lanka Malaysia Uruguay Cameroon UK Costa Rica PNG Fiji USA Peru South Africa Australia Korea

Genetic diversity

SIDR’s screening resources ~90% of plant families ~7,000 species of plants

What more do you get?

Flexible access chemistrybiology

Flexible access chemistry –samples for testing –96-well plates –isolation and structural elucidation –links with Drug Discovery Portal and med-chem biology

Flexible access chemistrybiology –molecular and cell- based assays –versatile detection  radioactivity  visible and uv light  chemiluminescence  fluorescence –96-well or 384-well formats

Work with an experienced and friendly team

Current assays cancer –anti-proliferative/ cytotoxicity assays on 20 human cancer cell lines –kinase inhibitors –cell adhesion blockers

Current assays cancer –anti-proliferative/ cytotoxicity assays on 20 human cancer cell lines –kinase inhibitors –cell adhesion blockers infection –S. aureus –E. coli –TB (M. marinum, N. farcinica) –parasitic diseases –cell growth and biofilm disruption

Current assays inflammation –anti-oxidant –cell proliferation –cell adhesion –TNF  signalling –NF  B pathway –kinases

Current assays inflammation –anti-oxidant –cell proliferation –cell adhesion –TNF  signalling –NF  B pathway neuro/metabolic –Alzheimer’s –analgesia –migraine –stroke –obesity –diabetes

Current “hit-to-lead” assays ADME-tox –hERG – cardiac toxicity –CACO2 – cellular absorption –micronucleus formation – genotoxicity –P450s – metabolic stability/drug interactions

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