VIROINDUCED ORAL CANCERS 7th Global Dentists and Pediatric Dentistry Meeting, 31 March-1st April 2016, Valencia-Spain.

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Presentation transcript:

VIROINDUCED ORAL CANCERS 7th Global Dentists and Pediatric Dentistry Meeting, 31 March-1st April 2016, Valencia-Spain

SRTRUCTURE OF VIRUSES

Etiopathogenesis Of Viroinduced Cancer

HUMAN PAPILLOMA VIRUS (HPV)

Schematic representation of the genomic organization of HPV 16

KAPOSI SARCOMA ASSOCIATED HERPES VIRUS ( KSHV OR HHV8)

Kaposi Sarcoma-associated Herpes Virus (KSHV ou HHV 8) (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:2-16) Endothelial cells Activation Inflammatory cytokines (IL- 6) Classic form of Kaposi Sarcoma Adhesion + extravasion Of the lymphocytes Fusiforme cells formation Angiogenesis Endothelial cells proliferation

Therapeutic Modalities For Clinical Variants Kaposi SarcomaTherapeutic Modalities For Clinical Variants Kaposi Sarcoma Br J Dermatol 2014;162:854-9

EPSTEIN BARR VIRUS ( EBV)

miRNAs can inhibit viral genes in order to avoid immune response and establish a latent infection. Herpesvirus 4 (HSV-4), also known as Epstein Barr virus (EBV), is an enveloped γ-herpesvirus which was discovered in 1964 by Anthony Epstein in Burkitt lymphoma samples from children living in Uganda. It has been classified as class I carcinogen virus by Agency for Research on Cancer. EBV was the first found encoding microRNAs (miRNAs) which can down- regulate gene expression and inhibit the apoptotic response of the infected cell. miRNAs can inhibit viral genes in order to avoid immune response and establish a latent infection.

BURKITT LYMPHOMA Burkitt lymphoma (BL) is a neoplasic disease that affects human B lymphocytes In untreated cases, it provokes death. BL is not frequent and usually affects to children aged 3-13 years with a peak of incidence at 6 years and it is more common in boys than girls. It is presented multifocal, but it is found typically in the area of the jaw

Endemic Sporadic Immunod eficiency associated 3 TYPES OF BURKITT LYMPHOMA (BL) -EBV can transform and drive B cells into unlimited proliferation in vitro. -Most tumour cells from endemic BL contains multiple EBV genomes and infectious virions can be found in tumour cell lines.

INTRAORAL EXAMINATION

TREATMENT OF EBV CANCER

HEPATITIS C VIRUS (HVC)

BUT

CONCLUSION