Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer by Yun ‐ Yong Park, Kyounghyun Kim,

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Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer by Yun ‐ Yong Park, Kyounghyun Kim, Sang ‐ Bae Kim, Bryan T. Hennessy, Soo Mi Kim, Eun Sung Park, Jae Yun Lim, Jane Li, Yiling Lu, Ana Maria Gonzalez ‐ Angulo, Woojin Jeong, Gordon B. Mills, Stephen Safe, and Ju ‐ Seog Lee EMBO Mol Med. Volume 4(1):52-67 January 2, 2012 ©2012 by European Molecular Biology Organization

NR gene network in NCI ‐ 60 cell lines. Yun ‐ Yong Park et al. EMBO Mol Med. 2012;4:52-67 ©2012 by European Molecular Biology Organization

NR2E3 is highly correlated with ESR1 in breast cancer patients. Yun ‐ Yong Park et al. EMBO Mol Med. 2012;4:52-67 ©2012 by European Molecular Biology Organization

NR2E3 regulates ESR1 function in breast cancer cells. Yun ‐ Yong Park et al. EMBO Mol Med. 2012;4:52-67 ©2012 by European Molecular Biology Organization

NR2E3 maintains ESR1 function via direct binding to ESR1 promoter in breast cancer cells. Yun ‐ Yong Park et al. EMBO Mol Med. 2012;4:52-67 ©2012 by European Molecular Biology Organization

PIAS3 association with ESR1 via NR2E3. Yun ‐ Yong Park et al. EMBO Mol Med. 2012;4:52-67 ©2012 by European Molecular Biology Organization

Expression of NR2E3 is significantly associated with recurrence of breast cancer. Yun ‐ Yong Park et al. EMBO Mol Med. 2012;4:52-67 ©2012 by European Molecular Biology Organization

NR2E3 is a prognostic factor in ER ‐ positive patients. Yun ‐ Yong Park et al. EMBO Mol Med. 2012;4:52-67 ©2012 by European Molecular Biology Organization

NR2E3 ‐ specific gene expression signatures. Yun ‐ Yong Park et al. EMBO Mol Med. 2012;4:52-67 ©2012 by European Molecular Biology Organization