Synthetic Chemistry for the Life Sciences Dial – a – Molecule Workshop, University of Liverpool Jan-12 Where / how can chemistry make greater contribution for Life Science benefit? Transforming Synthesis, Enabling Science

Transforming Synthesis, Enabling Science Proposed Themes & Outputs Dial–a–Molecule Workshop, University of Liverpool Jan-12 Fundamental LS Synthesis Glycosides, Nucleosides, Biomolecule oligomerisation, Metabolic processes Probes, kits, target validation 2 nd generation biologics, new medicines Calls to stimulate new innovation in difficult area CatalysisBiocatalysis Emulating nature’s reactions Bioengineering & harnessing nature CYP & other enzyme products, reaction cassettes, advanced manufacturing, green reaction toolkits/db, screen tools Lab of the Future; Catalysis for the Life Sciences - Call approach Synthesis for Biochemistry Synthesis, SAR for improved chemical tools as: Imaging diagnostics, histology aids specific organelle-staining agents, diagnostics for physiology of cells/ tissue, biomolecule attachment to surfaces, assaying, in vivo tracers Link to Nanotechnology; Subject for further meetings?

Transforming Synthesis, Enabling Science Proposed Themes & Outputs Dial–a–Molecule Workshop, University of Liverpool Jan-12 Biomolecule Design Simplified functionally dense Biomolecules (eg cyclic peptides), cheminformatics Probes, tools, aids for (academic) drug design, 2 nd generation biologics Academic Drug Discovery; Co-ordination (data collection, industry toolkit integration) Fluorine Chemistry Physical and synthetic chemistry for versatile F- introduction, CF3, CHF2 Biomimicry properties, drug design/ discovery, DMPK Call to stimulate new innovation Bio-pharm Synthesis Bioconjugate design, physical, analytical and synthetic chemistry Control of aggregation, stability, formulatability, transporter exploitation Possible stand-alone subject Predictive Toxicology Toxophore validation, computational methods Design toolkit, improved drug design Possible stand-alone subject; Co-ordination

Transforming Synthesis, Enabling Science Summary Dial–a–Molecule Workshop, University of Liverpool Jan-12 Many areas for which chemistry in its widest sense can make greater contribution to the pursuit of beneficial medicines Most have a requirement for more fundamental science – ie not the province of industry Life Sciences are not always aware of the contributions that chemistry can make – chemists are not always aware of the innovative benefit they can provide Q. Could Dial-a-Molecule demonstrate ‘catalysis’ in matching real problems with innovative chemistry ?