THE PROSTATE. NORMAL PROSTATE FIBROMUSCU – LAR stroma Glands with EPITHELIUM and BASAL CELLS.

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Presentation transcript:

THE PROSTATE

NORMAL PROSTATE FIBROMUSCU – LAR stroma Glands with EPITHELIUM and BASAL CELLS

prostate INFLAMMATION HYPERPLASIA NEOPLASIA

INFLAMMATION BACTERIAL, including TUBERCULOSIS IDIOPHATIC GRANULOMATOUS: The prostate becomes hard and irregular Elevated PSA Can be mistaken for cancer on palpation

Nodular / Adenofibromyomatous HYPERPLASIA

PROSTATE CANCER Almost always ADENOCARCINOMA 75 % of patients are > 75 years old Occurs in the peripheral zone Multifocal Scandinavia and the USA have the highest frequency; more common in blacks

How it is detected: An elevated PSA is found at urological examination ; Normal level: 4ng / ml Incidentially in TUR P material when hyperplasia is symptomatic

and diagnosed: Core biopsies (6 – 12 from the periphery of the prostate) Fine needle aspiration is nowadays done only to document an already known tumour

Prostatic Intraepithelial Neoplasia

PIN

<>

GLEASON GRADING

Gleason grade 2

GLEASON GRADE 3

Basal cells

GLEASON GRADE 3

Gleason grade 4

Gleson grade 5

Gleason grade 5

Perineural tumour growth