Date of download: 6/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: Reduction in Hemoglobin–Oxygen Affinity Results.

Slides:



Advertisements
Similar presentations
Date of download: 5/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: Renal ischemia/reperfusion remotely improves myocardial.
Advertisements

Date of download: 5/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: Increased myocardial apoptosis in patients with.
Date of download: 5/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: Remote Ischemic Conditioning Reduces Myocardial.
Date of download: 5/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: Contractile Function During Angiotensin-II Activation:
Date of download: 5/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: A Novel Inhibitory Effect of Naloxone on Macrophage.
Date of download: 5/29/2016 Copyright © The American College of Cardiology. All rights reserved. From: Prospective Application of Pre-Defined Intravascular.
Date of download: 5/29/2016 Copyright © The American College of Cardiology. All rights reserved. From: Renal Denervation in Moderate Treatment-Resistant.
Date of download: 5/30/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effects of Physical Exercise on Myocardial Telomere-Regulating.
Date of download: 5/30/2016 Copyright © The American College of Cardiology. All rights reserved. From: Noninvasive Quantification and Optimization of Acute.
Date of download: 5/30/2016 Copyright © The American College of Cardiology. All rights reserved. From: Transcriptome Characterization of Estrogen-Treated.
Date of download: 5/31/2016 Copyright © The American College of Cardiology. All rights reserved. From: Major Role for Hypoxia Inducible Factor-1 and the.
Date of download: 5/31/2016 Copyright © The American College of Cardiology. All rights reserved. From: Mitral Apparatus Assessment by Delayed Enhancement.
Date of download: 6/1/2016 Copyright © The American College of Cardiology. All rights reserved. From: A Relationship Between Vascular Endothelial Growth.
Date of download: 6/1/2016 Copyright © The American College of Cardiology. All rights reserved. From: Sonic Hedgehog-Induced Functional Recovery After.
Date of download: 6/2/2016 Copyright © The American College of Cardiology. All rights reserved. From: Different Effects of a High-Cholesterol Diet on Ischemic.
Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: A Novel Contrast Removal System From the Coronary.
Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: A comparison of three-year survival after coronary.
Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: SOCS1 Prevents Graft Arteriosclerosis by Preserving.
Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Irreversible Triggers for Hypertrophic Cardiomyopathy.
Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Right Ventricular Dysfunction and Remodeling in Chronic.
Date of download: 6/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Abnormal Skeletal Muscle Capillary Recruitment During.
Date of download: 6/9/2016 Copyright © The American College of Cardiology. All rights reserved. From: Cardiomyocyte-Specific Deletion of Gsk3α Mitigates.
Date of download: 6/9/2016 Copyright © The American College of Cardiology. All rights reserved. From: Navigator-Gated 3D Blood Oxygen Level–Dependent CMR.
Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Assessment of Advanced Coronary Artery Disease:
Date of download: 6/21/2016 Copyright © The American College of Cardiology. All rights reserved. From: A Novel Collagen Matricryptin Reduces Left Ventricular.
Date of download: 6/21/2016 Copyright © The American College of Cardiology. All rights reserved. From: Human Ventricular Unloading Induces Cardiomyocyte.
Date of download: 6/21/2016 Copyright © The American College of Cardiology. All rights reserved. From: Prediction of Cardiac Events in Patients With Reduced.
Date of download: 6/21/2016 Copyright © The American College of Cardiology. All rights reserved. From: Improved Survival of Patients With End-Stage Heart.
Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: Nebivolol Exerts Beneficial Effects on Endothelial.
Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: EUK-8, a Superoxide Dismutase and Catalase Mimetic,
Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: Homocysteine Modulates the CD40/CD40L System J Am.
Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: Does acute improvement of endothelial dysfunction.
Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: Increased Expression of Adenosine Triphosphate-Sensitive.
Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: Loss of Cardiac Magnesium in Experimental Heart.
Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: 17-Beta-Estradiol increases cardiac remodeling and.
Date of download: 6/25/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effect of ATP-Sensitive Potassium Channel Agonists.
Date of download: 6/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effects of Renal Sympathetic Denervation on Arterial.
Date of download: 6/29/2016 Copyright © The American College of Cardiology. All rights reserved. From: Synergistic Effects of Combined Cell Therapy for.
Date of download: 7/2/2016 Copyright © The American College of Cardiology. All rights reserved. From: Vascular Pathophysiology in Response to Increased.
Date of download: 7/2/2016 Copyright © The American College of Cardiology. All rights reserved. From: Abnormal Exercise Response in Long-Term Survivors.
Date of download: 7/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Myocardial Edema as Detected by Pre-Contrast T1 and.
Date of download: 7/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Cotransfection of Vascular Endothelial Growth Factor-A.
Date of download: 7/5/2016 Copyright © The American College of Cardiology. All rights reserved. From: Recovery of Myocardial Perfusion in Acute Myocardial.
Date of download: 7/5/2016 Copyright © The American College of Cardiology. All rights reserved. From: Oxidative capacity of skeletal muscle in heart failure.
Date of download: 7/5/2016 Copyright © The American College of Cardiology. All rights reserved. From: Value of Platelet Reactivity in Predicting Response.
Date of download: 7/5/2016 Copyright © The American College of Cardiology. All rights reserved. From: Ventricular Arrhythmia After Cardiac Surgery: Incidence,
Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Low concentrations of 17β-estradiol protect single.
Date of download: 7/6/2016 Copyright © The American College of Cardiology. All rights reserved. From: Cross-Sectional Assessment of the Effect of Kidney.
Date of download: 7/7/2016 Copyright © The American College of Cardiology. All rights reserved. From: Sustained Release of Erythropoietin Using Biodegradable.
Date of download: 7/7/2016 Copyright © The American College of Cardiology. All rights reserved. From: Stem Cell Mobilization by Granulocyte Colony-Stimulating.
Date of download: 7/7/2016 Copyright © The American College of Cardiology. All rights reserved. From: Isolated Quadriceps Training Increases Maximal Exercise.
Date of download: 7/7/2016 Copyright © The American College of Cardiology. All rights reserved. From: Intracoronary Cardiosphere-Derived Cells After Myocardial.
Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: A combination of oral endothelin-areceptor antagonist.
Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Load-Reducing Therapy Prevents Development of Arrhythmogenic.
Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Randomized Trial of Paclitaxel- Versus Sirolimus-Eluting.
Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Association of cardiac troponin, CK-MB, and postoperative.
Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Tolerability and efficacy of carvedilol in patients.
Date of download: 7/9/2016 Copyright © The American College of Cardiology. All rights reserved. From: Fibroblast growth factor-1 improves cardiac functional.
Date of download: 7/10/2016 Copyright © The American College of Cardiology. All rights reserved. From: Healthy Lifestyle and Decreasing Risk of Heart Failure.
Date of download: 9/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Phasic coronary blood flow velocity pattern and.
Date of download: 9/19/2016 Copyright © The American College of Cardiology. All rights reserved. From: Endothelial Nitric Oxide Synthase Overexpression.
Date of download: 9/20/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effect of Aging on Human Mesenchymal Stem Cell Therapy.
Date of download: 11/11/2016 Copyright © The American College of Cardiology. All rights reserved. From: Downregulated Expression of Plasminogen Activator.
Date of download: 11/12/2016 Copyright © The American College of Cardiology. All rights reserved. From: Moderate and chronic hemodynamic overload of sheep.
Date of download: 11/13/2016 Copyright © The American College of Cardiology. All rights reserved. From: The Reality of Heart Failure in Latin America J.
Respiration 2012;83:74–80 - DOI: /
Volume 8, Issue 4, Pages (April 2011)
Hironori Hara et al. BTS 2018;3:
Sebastiano Sciarretta et al. JACC 2018;71:
Presentation transcript:

Date of download: 6/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: Reduction in Hemoglobin–Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice With Chronic Heart Failure J Am Coll Cardiol. 2008;52(9): doi: /j.jacc Characterization of Transplanted BMCs (A) Detection of Presbyterian β (β Pres )-globin. Reversed-phase high-performance liquid chromatography profiles of hemolysate prepared from WT (top) or Presbyterian bone marrow cell (BMC)-transplanted (bottom) mice. The peaks of α-globin, WT (β WT - globin), and β Pres -globin are indicated. (B) The O 2 dissociation curves of the red blood cells from WT and Presbyterian BMC- transplanted mice measured at pH 7.4 (open circles and triangles) or at pH 6.9 (closed circles and triangles). Circles and triangles indicate WT and Presbyterian BMC transplanted mice, respectively. BMT = bone marrow cell transplantation; Pres = Presbyterian; WT = wild type. Figure Legend:

Date of download: 6/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: Reduction in Hemoglobin–Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice With Chronic Heart Failure J Am Coll Cardiol. 2008;52(9): doi: /j.jacc Characterization of MI and BMT Mouse Hearts (A) Experimental protocol. The LCA ligation operation was performed on 8-week-old WT mice. Four weeks after LCA ligation, echocardiographic analysis was performed and BMCs were transplanted into the lethally irradiated WT mice. Then, 4 weeks after BMT, the mice were echocardiographically analyzed again and subjected to the treadmill test. (B) Echocardiographic analysis findings before BMT (4 weeks post-operatively) and before the treadmill test (8 weeks post-operatively). (C) Hemodynamic data of the mice 4 weeks after BMT. Light blue, blue, yellow, and red bars represent Sham-WT BMT, MI-WT BMT, Sham-Pres BMT, and MI- Pres BMT, respectively. (D) Morphometric data from the mice 4 weeks after BMT. (E) Hematoxylin-eosin stain of heart section and cross-sectional area of cardiomyocytes at remote area. (F) Cardiac fibrosis in border and remote area with Azan-Mallory staining. BMC = bone marrow cell; HR = heart rate; HW/BW = heart weight to body weight ratio; LCA = left coronary artery; lungW/BW = lung weight-to-body weight ratio; LVSP = left ventricular systolic pressure; MI = myocardial infarction; other abbreviations as in Figure 1. Figure Legend:

Date of download: 6/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: Reduction in Hemoglobin–Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice With Chronic Heart Failure J Am Coll Cardiol. 2008;52(9): doi: /j.jacc Effect of Pres BMT on Exercise Capacity in MI Mice (A and B) Physical activity of BMT mice on a treadmill. Total rest time is shown in (A). Data represent the means ± SEM (n = 7). *p < 0.05 versus other groups. The distance run is shown in (B). Open triangles and closed circles represent MI-Pres BMT and MI-WT BMT, respectively. Data indicate the means ± SEM (n = 7). *p < 0.05 versus at corresponding time point. (C) Changes in tissue O 2 (PtiO 2 ) in BMT mice during hypoxia. Closed circles and open triangles indicate MI-WT and -Pres BMT mice, respectively. Data show the means ± SEM (n = 3). *p < 0.05 versus at corresponding time point. (D) Serum lactate level in BMT mice after exercise. Data represent the means ± SEM (n = 6 for MI-WT BMT mice and n = 8 for MI-Pres BMT mice). *p < Abbreviations as in Figures 1 and 2. Figure Legend:

Date of download: 6/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: Reduction in Hemoglobin–Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice With Chronic Heart Failure J Am Coll Cardiol. 2008;52(9): doi: /j.jacc Histological and Biochemical Analyses of Skeletal Muscles in BMT Mice (A) Transverse sections of the deep region in the tibialis anterior muscle were stained for adenosine triphosphatase activity (top) and for succinate dehydrogenase (SDH) activity (bottom). Scale bars indicate 50 μm. Quantitative analysis results for muscle type distribution and SDH activity are shown in B and C, respectively. (D) Total SDH activity from tibialis anterior muscle measured by enzymological methods (n = 3 for WT-BMT and n = 5 for Pres-BMT mice). (E and F) Endothelial cells were identified by staining with von Willebrand factor antibody. Capillary density was calculated by counting the numbers of capillaries in 20 random high-power fields (×400 power). Scale bars indicate 50 μm. Abbreviations as in Figures 1 and 2. Figure Legend:

Date of download: 6/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: Reduction in Hemoglobin–Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice With Chronic Heart Failure J Am Coll Cardiol. 2008;52(9): doi: /j.jacc Effect of RSR13 on Exercise Capacity of MI Mice (A) Chemical structure of RSR13. (B) Effect of RSR13 on running distance by normal mice. Thirty minutes after RSR13 or vehicle injection, the exercise test was started. Total distance run for each 30-min period are shown. C = vehicle-treated control group; R = RSR13-treated group. (C and D) Effect of RSR13 on exercise capacity of MI mice. Four weeks after LCA ligation, RSR13 or vehicle was injected into the mice (n = 4 each), and 30 min after the injection, the exercise test was started. Total rest time and distance run for each 30-min period are shown in C and D, respectively. Data show the means ± SEM. *p < 0.05 versus corresponding control subjects. Abbreviations as in Figure 2. Figure Legend: