ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: Automated TB diagnosis Robot Microscope Project Development Plan and Background ConsultASK Ltd

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: Facts about TB incidence With 8.8 Mi new cases annually and almost 2 Mi deaths, TB is still a leading mortality factor Overall, one-third of the world's population is currently infected with the TB bacillus. 10% of people who are infected with TB bacilli (but who are not infected with HIV) become sick or infectious at some time during their life. TB is the leading killer of people with HIV 27 countries account for 85% of MDR-TB cases There is huge need for tools that correspond to the medical need at affordable price (WHO report) Annually over USD 1 Bi wss spent on TB diagnostics in 2009, and the sum is increasing Source WHO Nearly 5,000 people die from TB daily, a curable disease in most cases !!

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: Further Facts The most commonly used sputum smear microscopy is more than 100 years old, but is the most affordable for the majority of HBC countries It is also the most ineffective, detects only half of patients tested with currently used manual method, mainly due to low sensitivity, lack of well trained personel, tiring factor. The vast majority of TB patients can be successfully treated with existing drugs, Delay in assessing proper diagnostics costs time, money and leads to continued transmission of infections TB drains 12 billion USD from the annual incomes of the poorest communities Loss of productivity attributable to TB approaches 7% of GDP in some countries Source WHO IT IS NOT AN UNCURABLE DISEASE! There is urgent need for more accurate and rapid diagnostic tests (WHO, FIND)

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: The Shocking Facts about TB

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: TB Burden Source WHO

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: Sputum smear diagnosis of TB: Light source microscopy ZN staining The fastest and cheapest available method Good specificity Weak sensitivity Trained staff needed Time consuming,10– 15 min./slide Fluorescence microscopy Increased sensitivity More expensive Faster, less tiresome Maintenance requirements (mercury vapour lamps )

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: Current market (WHO) Source WHO

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: Current smear market (WHO) Source WHO

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: The Global Revised WHO Plan

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: Current smear market Source WHO

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: Market cont. Current assumptions: –Number of microscopy centers ~70K (58K public, 12K private) –20% of microscopes should be replaced by LED by 2015 (WHO) –1 smear laboratory/ population should be reached by 2015 (WHO) Source WHO - Potential smear market 200 M tests (WHO)

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: Fluorobot: the fully automated solution Based on the traditional smear microscopy principle LED fluorescent technique Fully automated –Input / output and moving of the slides –Image capturing and analysis –Intelligent bacterium recognition algorythms Long walk away time Low cost, robust design suitable for high incidence, high burden countires

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: Main Features Illumination system using LED technology, much less sensitive, longer lifetime and cheaper than mercury vapour lamps Robust, cost effective X-Y movement Special, fast focusing system Cost effective, dedicated simplified microscope with only one magnification Special image processing and pattern recognition algorithms used for bacteria identification Walk away system, batch processing of 100 – 250 slides Standardised quality, no tiring effect No trained staff needed

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: Major milestones Feasibility Study in Q Functional Model stage was successfully reached Q Laboratory Sample Stage was reached at Q „Proof Of Principle” study was conducted at German TB Reference Laboratory, WHO Supranational Laboratory at Borstel led by Dr. Rüsch-Gerdes in September 2010, with positive outcome „Letter Of Intent” was signed with FIND (Foundation for Innovative New Diagnostics, Geneva) in November 2010 Financing Partner is searched in, to carry the project through Prototype Development (Q3 2012) and Validation (Q1 2013) Industrialization and Test Production Planned Q GoLive of final product (and disposable) planned Q4 2013

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: The new Laboratory Sample

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: What we propose Finalize potential disposable kit (staining kit, slide, slide holder…) Based on the results decide to continue or abort project Join the actual state of the development project and finance further development to Milestone III.) Continue to MS IV. Continue dedicated disposable development If successful continue with ConsultASK on industrialization of product Consider setting up production in Hungary (or partly or wholly in more cost effective environment if necessary) and supply of disposable, with a 3rd round financing

ConsultASK Management Consulting LLC H-1121 Budapest, Konkoly-Thege M. út Tel.: FAX: The Road behind our development team Core team has more than 15 years experience in medical imaging and robotic microscopy Main project in the early 90s was the Seditron urine sediment analyzer developed and produced for Boehringer Mannheim