Date of download: 6/28/2016 Copyright © 2016 SPIE. All rights reserved. Dependence of the source-size correction factor CE on the retinal irradiance diameter. Figure Legend: From: Variation of laser-induced retinal injury thresholds with retinal irradiated area: 0.1-s duration, 514-nm exposures J. Biomed. Opt. 2007;12(2): doi: /

Date of download: 6/28/2016 Copyright © 2016 SPIE. All rights reserved. System for exposure of monkey retina in vivo to a laser beam having selectable irradiance diameters at the retina. Figure Legend: From: Variation of laser-induced retinal injury thresholds with retinal irradiated area: 0.1-s duration, 514-nm exposures J. Biomed. Opt. 2007;12(2): doi: /

Date of download: 6/28/2016 Copyright © 2016 SPIE. All rights reserved. ED50 for laser-induced retinal injury in monkey eyes as a function of the retinal irradiance diameter for 100-ms-duration exposures to laser radiation from an argon laser operating at 514nm: open triangle, 1-h endpoint, extramacular exposures; closed triangle, 24 ‐ h endpoint, extramacular exposures; open circles, 1 ‐ h endpoint, macular exposures; closed circles, 24 ‐ h endpoint, macular exposures. Figure Legend: From: Variation of laser-induced retinal injury thresholds with retinal irradiated area: 0.1-s duration, 514-nm exposures J. Biomed. Opt. 2007;12(2): doi: /

Date of download: 6/28/2016 Copyright © 2016 SPIE. All rights reserved. Comparison of the ED50 for retinal injury induced by 100-ms-duration, 514 ‐ nm laser exposures (triangles)(this paper) with the ED50 for retinal injury induced by 7-ns-duration 532nm laser exposures (diamonds). The data show the dependence on retinal irradiance diameter for a 24-h postexposure observation time. Open symbols represent macular ED50s; closed symbols represent extramacular ED50s; the long-dashed line represent the MPE for 100-ms exposure duration, and the short-dashed line represents the MPE for 7-ns exposure duration. Figure Legend: From: Variation of laser-induced retinal injury thresholds with retinal irradiated area: 0.1-s duration, 514-nm exposures J. Biomed. Opt. 2007;12(2): doi: /

Date of download: 6/28/2016 Copyright © 2016 SPIE. All rights reserved. Dependence of ED50 on the retinal irradiance diameter for a range of exposure durations and laser wavelengths: squares, 150fs and 1060nm (Ref. ); circles, 7ns and 532nm (Refs. ); inverted triangles, 3μs and 590nm (Refs. ); diamonds, 100ms and 514nm (this paper); triangles, to 1s and 633nm (Ref. ). Figure Legend: From: Variation of laser-induced retinal injury thresholds with retinal irradiated area: 0.1-s duration, 514-nm exposures J. Biomed. Opt. 2007;12(2): doi: /

Date of download: 6/28/2016 Copyright © 2016 SPIE. All rights reserved. Possible changes to the nano- to microsecond-duration MPE to reflect the D2 dependence of threshold for large irradiance diameter while providing a margin of safety at all irradiance diameters. The change might require either an increase in Dmin(αmin) or a decrease in the point-source MPE. Squares, macular ED50 for 7-ns exposures at 590nm; narrow line, current MPE for 1-ns to 18- ms exposure; bold line, possible forms of revised MPE. Figure Legend: From: Variation of laser-induced retinal injury thresholds with retinal irradiated area: 0.1-s duration, 514-nm exposures J. Biomed. Opt. 2007;12(2): doi: /

Date of download: 6/28/2016 Copyright © 2016 SPIE. All rights reserved. Comparison of the dependence of ED50 on irradiance diameter for in vivo exposures (monkey eyes) and in vitro exposures (retinal explants): triangles, 100-ms, 514 ‐ nm, 24-h endpoint macular data in monkey (this study); diamonds, 100-ms, 532 ‐ nm data, cell death endpoint data in retinal explant; circles, 7-ns, 532 ‐ nm, 24-h endpoint macular data in monkey; squares, 100-ps, 532 ‐ nm cell death endpoint data in retinal explant. The MPE is included for 100-ms-duration exposures (long-dashed line) and nanosecond- duration exposures (short-dashed line). The explant data represents the energy at the explant surface. Figure Legend: From: Variation of laser-induced retinal injury thresholds with retinal irradiated area: 0.1-s duration, 514-nm exposures J. Biomed. Opt. 2007;12(2): doi: /