What we know Halogen (Grp 7) Yellow-green gas Elec. Config: [Ne] 3s 2 3p 5 3 rd most Electronegative Strong Oxidizer Commonly: NaCl salt.

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Presentation transcript:

What we know Halogen (Grp 7) Yellow-green gas Elec. Config: [Ne] 3s 2 3p 5 3 rd most Electronegative Strong Oxidizer Commonly: NaCl salt

Used in warfare

Chlorine in Biology ? Gastric Gland Lumen ---- Proximal Tube Lumen

Kidney Nephron

Cystic Fibrosis (mucoviscidosis) Congenital Absence of vas Deferens Meconium ileus Pancreatitis (CFTR-type) Gall stones (CFTR-type) Cholera Cl-related Disease

Cystic Fibrosis

Defined: Inherited Dx. characterized by the buildup of thick, sticky mucus Most common fatal genetic disease Prevalence : 1 in 2,500 babies (UK) 1 in 3,600 babies (Ca) Affects many organs - sp: Lung, pancreas, skin Etiology: CFTR mutation

The CFTR protein is a channel protein that controls the flow of H 2 O & Cl − ions

Improved Life Expectancy with medical advancements

CF Initial Signs Salty Skin Baby does not pass stool when born Dehydration Frequent coughing Unnaturally Thick sputum Frequent Resp. infections (e.g. sinusitis, bronchitis) Diarrhea or bulky, foul-smelling, greasy stools Aspermia, Female infertility

Clubbing