What we know Halogen (Grp 7) Yellow-green gas Elec. Config: [Ne] 3s 2 3p 5 3 rd most Electronegative Strong Oxidizer Commonly: NaCl salt
Used in warfare
Chlorine in Biology ? Gastric Gland Lumen ---- Proximal Tube Lumen
Kidney Nephron
Cystic Fibrosis (mucoviscidosis) Congenital Absence of vas Deferens Meconium ileus Pancreatitis (CFTR-type) Gall stones (CFTR-type) Cholera Cl-related Disease
Cystic Fibrosis
Defined: Inherited Dx. characterized by the buildup of thick, sticky mucus Most common fatal genetic disease Prevalence : 1 in 2,500 babies (UK) 1 in 3,600 babies (Ca) Affects many organs - sp: Lung, pancreas, skin Etiology: CFTR mutation
The CFTR protein is a channel protein that controls the flow of H 2 O & Cl − ions
Improved Life Expectancy with medical advancements
CF Initial Signs Salty Skin Baby does not pass stool when born Dehydration Frequent coughing Unnaturally Thick sputum Frequent Resp. infections (e.g. sinusitis, bronchitis) Diarrhea or bulky, foul-smelling, greasy stools Aspermia, Female infertility
Clubbing