Pluripotent stem cells: private obsession and public expectation by Austin Smith EMBO Mol Med. Volume 2(4):113-116 April 1, 2010 ©2010 by European Molecular.

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Pluripotent stem cells: private obsession and public expectation by Austin Smith EMBO Mol Med. Volume 2(4): April 1, 2010 ©2010 by European Molecular Biology Organization

LIF reinforces the pluripotent transcription factor hubOct4/Sox along with Nanog and Klfs comprise an autoregulatory hub that radiates to sustain the pluripotency gene regulatory network. Austin Smith EMBO Mol Med. 2010;2: ©2010 by European Molecular Biology Organization

From pluripotency to lineage ‐ specific differentiationIn this model ES cells must first exit the ground state to generate effector cells that are enabled for lineage specification and differentiation. Austin Smith EMBO Mol Med. 2010;2: ©2010 by European Molecular Biology Organization

Biomedical potential of pluripotent stem cellsAs a renewable source for all types of differentiated cell, human pluripotent stem cells provide unprecedented opportunities for studying human cellular pathogenesis and for developing efficacious pharmaceuticals. Austin Smith EMBO Mol Med. 2010;2: ©2010 by European Molecular Biology Organization