Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody Sophie E. Broughton, Timothy R. Hercus, Matthew P. Hardy, Barbara J. McClure,

Slides:



Advertisements
Similar presentations
Waging War on Cancer with the Sword of Immunity Cell Volume 158, Issue 2, (July 2014) DOI: /j.cell Copyright © 2014 Terms and Conditions.
Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
A Role for Dystroglycan in Basement Membrane Assembly Michael D Henry, Kevin P Campbell Cell Volume 95, Issue 6, Pages (December 1998) DOI: /S (00)
Genome Engineering with CRISPR-Cas9 in the Mosquito Aedes aegypti
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle Hangjun Ke, Ian A. Lewis, Joanne M. Morrisey, Kyle J.
Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors Liang Yang, Yong Qi, Yunlei Yang Cell Reports Volume 11, Issue.
Irreplaceability of Neuronal Ensembles after Memory Allocation Naoki Matsuo Cell Reports Volume 11, Issue 3, Pages (April 2015) DOI: /j.celrep
In Vivo RNAi Screening Identifies MDA5 as a Significant Contributor to the Cellular Defense against Influenza A Virus Asiel A. Benitez, Maryline Panis,
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity Michael S. Rooney, Sachet A. Shukla, Catherine J. Wu, Gad Getz,
Grid Cells Form a Global Representation of Connected Environments Francis Carpenter, Daniel Manson, Kate Jeffery, Neil Burgess, Caswell Barry Current Biology.
Mitotic Spindle Asymmetry: A Wnt/PCP-Regulated Mechanism Generating Asymmetrical Division in Cortical Precursors Delphine Delaunay, Véronique Cortay, Dorothée.
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.
Multifaceted roles for lipids in viral infection Nicholas S. Heaton, Glenn Randall Trends in Microbiology Volume 19, Issue 7, Pages (July 2011)
Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm Jianbin Wang, H. Christina Fan, Barry Behr, Stephen.
Consecutive Positive Feedback Loops Create a Bistable Switch that Controls Preadipocyte-to-Adipocyte Conversion Byung Ouk Park, Robert Ahrends, Mary N.
The Dynamics and Mechanics of Endothelial Cell Spreading Cynthia A. Reinhart-King, Micah Dembo, Daniel A. Hammer Biophysical Journal Volume 89, Issue 1,
Parallel Compensatory Evolution Stabilizes Plasmids across the Parasitism-Mutualism Continuum Ellie Harrison, David Guymer, Andrew J. Spiers, Steve Paterson,
Human Gut Microbes Use Multiple Transporters to Distinguish Vitamin B12 Analogs and Compete in the Gut Patrick H. Degnan, Natasha A. Barry, Kenny C. Mok,
Charting Monosynaptic Connectivity Maps by Two-Color Light-Sheet Fluorescence Microscopy Christian J. Niedworok, Inna Schwarz, Julia Ledderose, Günter.
Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome David A. Orlando, Mei Wei Chen, Victoria E. Brown, Snehakumari Solanki,
Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels Jacqueline Thorburn, Zdenek Andrysik, Leah Staskiewicz,
Mechanism and Regulation of Rapid Telomere Prophase Movements in Mouse Meiotic Chromosomes Chih-Ying Lee, Henning F. Horn, Colin L. Stewart, Brian Burke,
Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease Roshni Srivastava, Jiasheng Zhang, Gwang-woong.
Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell
Rapamycin Prevents the Development and Progression of Mutant Epidermal Growth Factor Receptor Lung Tumors with the Acquired Resistance Mutation T790M Shigeru.
The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.
Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression Charikleia Papadopoulou, Guillaume Guilbaud, Davide Schiavone,
Structure of the SecY Complex Unlocked by a Preprotein Mimic Dilem Hizlan, Alice Robson, Sarah Whitehouse, Vicki A. Gold, Janet Vonck, Deryck Mills, Werner.
Lever-Arm Mechanics of Processive Myosins Yujie Sun, Yale E. Goldman Biophysical Journal Volume 101, Issue 1, Pages 1-11 (July 2011) DOI: /j.bpj
A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair Julian Stingele, Michael S. Schwarz, Nicolas Bloemeke, Peter G. Wolf, Stefan Jentsch.
Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6 Chong Yew Tan, Samuel Virtue, Guillaume Bidault, Martin Dale, Rachel Hagen, Julian L.
Noncanonical Genomic Imprinting Effects in Offspring Paul J. Bonthuis, Wei-Chao Huang, Cornelia N. Stacher Hörndli, Elliott Ferris, Tong Cheng, Christopher.
Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector Tural Aksel, Elizabeth Choe Yu, Shirley Sutton, Kathleen.
Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Embryonic Stem Cell Differentiation Mohan Malleshaiah, Megha Padi, Pau Rué, John Quackenbush,
WHAMM Is an Arp2/3 Complex Activator That Binds Microtubules and Functions in ER to Golgi Transport Kenneth G. Campellone, Neil J. Webb, Elizabeth A. Znameroski,
MiR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells Mathieu Neault, Frédérick A. Mallette, Stéphane Richard Cell.
Contribution of Aberrant GluK2-Containing Kainate Receptors to Chronic Seizures in Temporal Lobe Epilepsy Angélique Peret, Louisa A. Christie, David W.
NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs Shobbir Hussain, Abdulrahim A. Sajini,
ABH2 Couples Regulation of Ribosomal DNA Transcription with DNA Alkylation Repair Pishun Li, Shuman Gao, Lina Wang, Fang Yu, Jialun Li, Chuangui Wang,
2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.
Differential drug responses of circulating tumor cells within patient blood Andrew D. Hughes, Jocelyn R. Marshall, Eric Keller, John D. Powderly, Bryan.
Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron
Phospholipid-Cholesterol Bilayers under Osmotic Stress Emma Sparr, Linda Hallin, Natalia Markova, Håkan Wennerström Biophysical Journal Volume 83, Issue.
Oscillatory Activity in Developing Prefrontal Networks Results from Theta-Gamma- Modulated Synaptic Inputs Sebastian H. Bitzenhofer, Kay Sieben, Kai D.
DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism Yasuto Murayama, Frank Uhlmann Cell Volume 163, Issue 7, Pages
Oxidative stress and hypoxia in normal and leukemic stem cells Ugo Testa, Catherine Labbaye, Germana Castelli, Elvira Pelosi Experimental Hematology Volume.
Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic Vincent J. Lynch, Oscar C. Bedoya-Reina, Aakrosh Ratan, Michael.
Volume 1, Issue 6, Pages (December 2013)
In This Issue Cell Volume 158, Issue 5, (August 2014)
Volume 24, Issue 8, Pages (August 2016)
Volume 13, Issue 7, Pages (November 2015)
Volume 152, Issue 1, (January 2013)
Tribute to Jonna Barry Wilderness & Environmental Medicine
Volume 130, Issue 6, (September 2007)
More Than Many: How to Manage the Most Frequent Cancer?
Volume 143, Issue 6, (December 2010)
No expectation to share incidental findings in genomic research
Rapid Automatic Motor Encoding of Competing Reach Options
Andrew R. Bassett, Charlotte Tibbit, Chris P. Ponting, Ji-Long Liu 
Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development  Summer B. Thyme, Alexander F. Schier 
Volume 163, Issue 4, (November 2015)
Volume 163, Issue 2, (October 2015)
Exercise in Individuals With CKD: A Focus Group Study Exploring Patient Attitudes, Motivations, and Barriers to Exercise  Jessica Kendrick, Michael Ritchie,
Management of thin endometrium in assisted reproduction: a clinical practice guideline from the Canadian Fertility and Andrology Society  Kimberly E.
Volume 11, Issue 7, Pages (May 2015)
Volume 134, Issue 6, (September 2008)
In This Issue Cell Volume 145, Issue 3, (April 2011)
Volume 148, Issue 1, (January 2012)
Presentation transcript:

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody Sophie E. Broughton, Timothy R. Hercus, Matthew P. Hardy, Barbara J. McClure, Tracy L. Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F. Barry, Winnie L. Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J. Busfield, Catherine M. Owczarek, Andrew D. Nash, Nicholas J. Wilson, Michael W. Parker, Angel F. Lopez Cell Reports Volume 8, Issue 2, Pages (July 2014) DOI: /j.celrep Copyright © 2014 The Authors Terms and Conditions Terms and Conditions

Figure 1 Cell Reports , DOI: ( /j.celrep ) Copyright © 2014 The Authors Terms and Conditions Terms and Conditions

Figure 2 Cell Reports , DOI: ( /j.celrep ) Copyright © 2014 The Authors Terms and Conditions Terms and Conditions

Figure 3 Cell Reports , DOI: ( /j.celrep ) Copyright © 2014 The Authors Terms and Conditions Terms and Conditions

Figure 4 Cell Reports , DOI: ( /j.celrep ) Copyright © 2014 The Authors Terms and Conditions Terms and Conditions

Figure 5 Cell Reports , DOI: ( /j.celrep ) Copyright © 2014 The Authors Terms and Conditions Terms and Conditions

Cell Reports , DOI: ( /j.celrep ) Copyright © 2014 The Authors Terms and Conditions Terms and Conditions