P. Lecoq CERN 1 October 2010 Physics & Technology at CERN, Bogota, October 20-22, European Centre for Research in Medical Imaging

P. Lecoq CERN 2 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 CERIMED in a few words A pluridisciplinary research center in medical imaging A European Open Campus with 6 departments –Biomedical imaging instrumentation –Imaging probes –Preclinical imaging –Clinical imaging –Education & Training –Industrial incubation

P. Lecoq CERN 3 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 CERIMED in a few dates 2002: CERIMED Concept developed at CERN 2003: Recognized and supported as an important component of the Cancer Plan by the French Ministry of Health 2005: the Université de la Méditerranée in Marseille receives the mandate to build CERIMED 2007: 23 M€ Funding raised (OPTITEC Competitivity cluster) –French central government –Regional government –EU infrastructure funds : 7M€ additionnal equipment –July 2008: agreement with Canada for a high power femtosecond laser –July 2009: contract with Advanced Accelerator Applications for 2 cyclotrons and 3 radiopharmaceutical labs Mid 2012: Scheduled delivery of the CERIMED infrastructure

P. Lecoq CERN 4 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 CERIMED: a complete and versatile infrastructure A radiochemistry unit –2 cyclotrons and 3 radiopharmaceutical labs A high power femtosecond laser (in collaboration with Canada) A preclinical imaging platform for both small and large animals –With all imaging modalities and a large capacity animal house A fully equipped clinical research center –Integrated in the Marseille Clinical Investigation Center A full set of technical workshops and a large assembly hall A Technoparc for the industrial partners A 30M€ infrastructure On the Timone University Hospital campus in Marseille Opening at the end of 2011

P. Lecoq CERN 5 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 University hospital Timone Health Campus CERIMED CERIMED building

P. Lecoq CERN 6 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 The building has a useful area of 2470m 2 (3648m 2 total surface), with an extention of 450m 2 for the femtosecond laser platform. 5 functional sectors:  Radiopharmaceutical sector 405m²  Technological sector 450 m²  Preclinical sector including animal handling ressources 473 m²  Clinical sector 359 m²  Tertiary sector (offices, meeting rooms, administration)783 m² CERIMED building

P. Lecoq CERN 7 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 CERIMED Building TERTIAIRE CLINIQUE TECHNOLOGIQUE RADIOPHARMACIE PRE-CLINIQUE

P. Lecoq CERN 8 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 TERTIAIRE CLINIQUE TECHNOLOGIQUE RADIOPHARMACIE PRE-CLINIQUE Flux des personnels Flux des visiteurs Flux des patients Flux des machines d’imagerie Flux des radioi isotopes CERIMED Flux des radioi isotopes AAA Flux des animaux CERIMED building

P. Lecoq CERN 9 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 Annual previsional budget10 M€ –Salaries 20 researchers (project leaders) 4 M€ –Salaries 20 technical/administrative staff 3 M€ –Contribution to research programs (seed money) 1.5 M€ –Equipment amortization 1 M€ (10%/year for technical, preclinical and clinical platforms) –Overhead expenditure 0.5 M€ Funding by Université de la Méditerranée and –Public-private foundation –Academic partnerships (Universities, Institutions, Hospitals) –Industrial contracts (research, services) –Funding agencies for National and International research programs OPERATIONNAL BUDGET: 10M€/year INFRASTRUCTURE: 30M€ Building12 M€ Equipment18 M€ –2 cyclotrons + 3 radiopharmaceutical labs 4 M€ –Technological workshops, preclinical and clinical platforms11 M€ –High power femtosecond laser platform 3 M€ CERIMED in numbers

P. Lecoq CERN 10 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 CERIMED status 15 ongoing projects –4 technical (1 small animal, 2 breast imaging, 1 TOFPET endoscope prostate-pancreas) Small animal: ClearPET XPAD (simultaneous PET/X-Ray) Breast imaging: ClearPEM-US (dedicated PET + US- elastography) Breast imaging: POCASI: (diffuse optical imaging) Endoscopy: PET-US probe with time of flight capability –9 clinical 4 in neurosciences 4 in oncology 1 in cardiology –2 education & training One international conference: EuroMedIm thematic workshops

P. Lecoq CERN 11 October 2010 Physics & Technology at CERN, Bogota, October 20-22, PET Data Acquisition Systems, Marseille, Sept 2006 In collaboration with IN2P3 2. Brain & Vascular Imaging, Rome, Nov 2006 In collaboration with INFN and Istituto Superiore di Sanita (ISS) 3. Breast Imaging, Marseille, Jan 2007 In collaboration with cancéropôles CLARA and PACA and Istituto Superiore di Sanita (ISS) 4. Brainstorming on CERIMED objectives and organization, Saint Maximin, Apr Stem Cell Imaging, Marseille, Dec 2008 In collaboration with Istituto Superiore di Sanita (ISS) 6. GPU Computing, Obernai, May 2009 In collaboration with IN2P3 7. Photonics in Imaging, Marseille, June 2009 In collaboration with OPTITEC 8. Intraoperative Imaging of Radioisotopes, Mattinata – Gargano, Sept 2009 In collaboration with INFN, IN2P3 and West Virginia University 9. Metabolic Signature of Cancers, Marseille, Dec 2009 In collaboration with cancéropôle PACA 10. Molecular Imaging and Biology in Oncology, Nice, Jan 2010 In collaboration with cancéropôle PACA and Münich Technical University Thematic workshops

P. Lecoq CERN 12 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 Workshop in preparation Advanced Multimodality Endoscopic Instruments in the Detection, Diagnosis, Therapy, and Follow-Up of Diseases Marseille, France January, 2011

P. Lecoq CERN 13 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 ClearPEM METABOLIC information Ultrasound Probe MORPHOLOGIC and STRUCTURAL information Objective: Detect 1 to 2mm tumors and define their cancerous status ClearPEM-Sonic a collaborative project between physicians and physicists

P. Lecoq CERN 14 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 Back APD Matrix Front APD Matrix 1 Module = 32 crystals 2x2x20mm Amplifiers FE Board 1 SuperModule = 6 matrices 1 Plate 17,3x15,5x3cm = 16 SuperModules = 3072 crystals New technologies ClearPEM ClearPEM

P. Lecoq CERN 15 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 Focus ultrasound beam in tissue Propagate focal point a t supersonic speed in breast Measure the deformation of the shock wave by a tumor 2 ms12 ms 17 ms New technologies Ultrasound Ultrasound

P. Lecoq CERN 16 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010ClearPET-XPAD ClearPET/XPAD Simultaneous hybrid PET/CT imaging system RTW X-ray tube Mo target, 50 µm focal spot size, 50 W Nb/Mo additional filter Collimated 17 keV almost monochromatic New Hybrid pixel X-ray camera XPAD3/Si Photon counting mode 500 µm silicon sensor thickness 78 x 75 mm² detector 130 x 130 µm² pixel size 36 mm axial FOV 35 mm transverse FOV Courtesy of C. Morel CPPM/CERIMED

P. Lecoq CERN 17 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010ClearPET-XPAD 22 Na source surgically inserted in the belly of a dead mouse Simultaneous PET and CT acquisition Courtesy of C. Morel CPPM/CERIMED

P. Lecoq CERN 18 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 Development of new biomarkers First clinical target: pancreatic cancer Tool: dual modality PET-US endoscopic probe –Spatial resolution: 1mm –Timing resolution: 200ps –High sensitivity to detect 1mm tumor in a few mn –Energy resolution: discriminate Compton events Endo TOFPET-US Novel multimodal endoscopic probes for simultaneous PET/ultrasound imaging for image-guided interventions

P. Lecoq CERN 19 October 2010 Physics & Technology at CERN, Bogota, October 20-22, 2010 CERIMED welcomes international collaborations