Hwa-Jin Lee Department of nuclear medicine, Pusan University Hospital Study on the Analysis of Comparison with GE prodigy and FRAX Tool in Absolute Fracture Risk Assessment Tool

Contents Purpose 1 Materials and Method 2 Results 3 Conclusion 4

Purpose Osteoporosis The silent disease  Loss of bone mass, breakdown in the microarchitecture of the bone  Slight bump or a fit of coughing can cause a fracture Osteoporotic Fracture  Serious Complication of Osteoporosis  Femoral Fracture : cases Death rate : 17%  Vertebral Fracture : Cases Death rate : 3.6%

Purpose

WHO FRAX TM ISCD International Society for Clinical Densitometry Reducing the present confusions Making the recommendation on clinically relevant issues - Every two years World Health Organization (2008) Studying population- based cohorts 10-year fracture probability Diagnosis, Therapy, Prevention,Fracture risk assessment of osteoporosis - New Clinical guidelines Fracture Risk Assessment Tool Sweden,US, UK, Italy, China, Spain, France, Japan. Turkey, Sweden, Switzerland, Austria Risk Factors

Purpose Secondary osteoporosis Previous fracture Current smoking Gluco corticoids Rheumatoid arthritis Risk Factors Parent fractured hip Alcohol 3 or more units/day

Purpose Fracture Risk Assessment GE Prodigy Over 50 years old Only Age and Bone density Software of GE Prodigy FRAX TM Over 40 years old Population-based cohorts from Europe, North America, Asia, Australia. The number of risk factors Web site

Materials Fracture risk Assessment 201 Women (50-60 years old) underwent Femoral Neck BMD measurement in PNUH Over 50 years old Over 40 years old GE Prodigy FRAX TM

GE Prodigy Femur Scan Dual energy X-ray Absorptiometry 15 degrees internal rotation Femoral neck BMD g/ ㎠ Method

Analysis T-SCORE Major osteoporosis-related fracture 10-year probability of hip fracture GE Prodigy Fracture risk calculator FRAX TM ac.uk/FRAX - Japan Femoral Neck BMD SPSS, Paired t-test, <0.05

Results  T-SCORE N Mean ± SD CorrelationSig GTFT GT & FT ± ± GT : T-score of GE Prodigy FT : T-score of FRAX TM

Results  T-SCORE GT : T-score of GE Prodigy FT : T-score of FRAX TM

Results  Major osteoporosis-related fracture N Mean ± SD CorrelationSig GANYFANY GANY & FANY ± ± GANY : a major osteoporosis-related fracture of GE prodigy FANY : a major osteoporosis-related fracture of FRAX TM

Results  Major osteoporosis-related fracture GANY : a major osteoporosis-related fracture of GE prodigy FANY : a major osteoporosis-related fracture of FRAX TM

Results  10-year probability of hip fracture N Mean ± SD CorrelationSig GHIPFHIP GHIP & FHIP ± ± GHIP : 10-year probability of hip fracture of GE prodigy FHIP : 10-year probability of hip fracture of FRAX TM

Results  10-year probability of hip fracture GHIP : 10-year probability of hip fracture of GE prodigy FHIP : 10-year probability of hip fracture of FRAX TM

Conclusion GE Prodigy Higher  T-score  A major osteoporosis- related fracture  The 10-year probability of hip fracture FRAX TM  BMD AND Fracture Risk  Diagnosis, Therapy, Prevention of Osteoporosis New Clinical Guidelines Limit  Assessment, Application for FRAX TM Studying population- based cohorts from Korea 1 2 3