Lysophosphatidic acid acts as a nutrient ‐ derived developmental cue to regulate early hematopoiesis by Haisen Li, Rui Yue, Bin Wei, Ge Gao, Jiulin Du,

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Lysophosphatidic acid acts as a nutrient ‐ derived developmental cue to regulate early hematopoiesis by Haisen Li, Rui Yue, Bin Wei, Ge Gao, Jiulin Du, and Gang Pei EMBO J. Volume ():e May 19, 2014 ©2014 by European Molecular Biology Organization

Pharmacological blockage of ATX ‐ LPA signaling inhibits hematopoietic differentiation ARepresentative flow cytometry data for CD41 staining in day 6 EBs, treated with DMSO or 30 μM Ki16425 from day 2 to day 6. Haisen Li et al. EMBO J. doi: /embj ©2014 by European Molecular Biology Organization

Genetic blockage of ATX–LPA signaling inhibits hematopoietic differentiation AqPCR analyses of lpar1 or lpar3 knockdown efficiency (n = 4 per group). Haisen Li et al. EMBO J. doi: /embj ©2014 by European Molecular Biology Organization

Pharmacological blockage of ATX ‐ LPA signaling inhibits hemangioblast formation Representative flow cytometry data for Flk1 staining in day 4 whole EBs. EBs were treated with DMSO or 30 μM Ki16425 from day 2 to day 4 and analyzed by flow cytometry. Haisen Li et al. EMBO J. doi: /embj ©2014 by European Molecular Biology Organization

Genetic blockage of ATX ‐ LPA signaling inhibits hemangioblast formation Effects of lpar1 and/or lpar3 knockdown on Flk1+ cell percentage in day 4 whole EBs (n = 4). qPCR analyses of hematopoietic and germ layer marker expressions (n = 4). Haisen Li et al. EMBO J. doi: /embj ©2014 by European Molecular Biology Organization

ATX–LPA signaling regulates hematopoietic differentiation through PI3K/Akt ‐ Smad pathway A,BFlow cytometry analyses of CD41+ cell percentage. Haisen Li et al. EMBO J. doi: /embj ©2014 by European Molecular Biology Organization

ATX–LPA signaling is required for hemangioblast formation and primitive hematopoiesis in zebrafish A–HWISH analyses for embryos treated with Ki Haisen Li et al. EMBO J. doi: /embj ©2014 by European Molecular Biology Organization