A.k.a : Muramidase OR N-acetylmuramide glycanhydrolase

Slides:

Advertisements

Similar presentations

Chapter 19 The Chemistry of Life.

Advertisements

Dehydration Synthesis (Condensation Reaction) Hydrolysis

Dehydration Synthesis (Condensation Reaction) Hydrolysis

Biochemistry Lysozyme – a protein. Chemical Bonds nonmetals Covalent bonds form between atoms of nonmetals by sharing of electrons - Molecules bond covalenty.

Premed Biology Final Review

Chapter 4 Part 3 The Cell Wall of Prokaryotes: Peptidoglycan and Related Molecules.

The Chemistry of Life! Organic Molecules AndWater.

Life with Carbon Chapter 8 Section 4

BIOCHEMISTRY REVIEW.  HOW MANY COVALENT BONDS MAY CARBON FORM WITH OTHER ATOMS?

35.2 Defenses against Infection

Functional Groups A group of atoms within a molecule that interacts in predictable ways with other molecules. Examples? Hydroxyl groups are hydrophilic.

Why do you need food? Food provides your body with materials to grow and repair tissues. It provides energy for everything you do. Your body breaks down.

The Immune System Pathogen : Viruses, bacteria, and other microorganisms that cause disease are called pathogens. Infection: Invasion of the tissues of.

Chemical Compounds in Cells and in Our Food pp & pp

Ch 35 The Immune System (parrot bk)

Carbon Chemistry Chapter 8

NAME: __________________________ Carbons with different elements join to make ____MACROMOLECULES__ “Organic” means a molecule contains __Carbon_________.

If a cell makes a lot of protein, what organelle must it also have a lot of? Ribosomes.

Biology Fall  Carbon is the main ingredient of organic molecules.  a.k.a biomolecules  Composed of a backbone of carbon atoms bonded to one another.

Example2: Building a protein from amino acids: Substrate: Amino acids Product: The protein.

Reginald H. Garrett Charles M. Grisham Chapter 1 The Facts of Life: Chemistry is the Logic of Biological Phenomena.

Biochemistry Chapter 3.

Most Common Elements in Living Things 1.Carbon - C 2.Hydrogen - H 3.Oxygen - O 4.Nitrogen - N Make up 95% of your body weight Organic Compounds – Have.

Review of Organic Macromolecules How Structure Meets Function.

Immune System. Disease A disease is any change other than injury, that disrupts the normal functions of the body. Some diseases are inherited, others.

2.5 Carbohydrates. Some Functions: –Quick fuel –Short-term energy storage –Structure of organisms –Cell to cell recognition.

Jonnathan Pineda. What is a Cell?  Make up living things  Carry out activities that keep them alive.

What our bodies are made of Chemistry of Cells. Nature of Matter All matter is made of atoms. Atoms consist of electrons, protons and neutrons. Molecules.

The Immune System Chapter 43. The Immune System  An animal must defend itself against:  Viruses, bacteria, pathogens, microbes, abnormal body cells,

Focus What property of water is this picture demonstrating and how.

Chemistry Chapter 2 Quizzes. Quiz 2.1 and ________ are the smallest unit of matter. 2.Atoms in molecules share electrons and form __________ bonds.

Chemical Compounds in Cells. Review of basic chemistry Element – any substance that cannot be broken down into a simpler substance –Ex – carbon, nitrogen,

MACROMOLECULES. The four macromolecules are: Carbohydrates Proteins Lipids Nucleic acids.

Ch. 2 Part 2 The Chemical Level of Organization. Inorganic vs. Organic Inorganic – Usually lack carbon – Structurally simple – Include: Water Salts Acids.

Biochemistry II 2 nd Semester /12.

Organic Compounds. Carbohydrates Carbohydrate Characteristics Carbon chain or ring bonded to O or H atoms - contain 2 atoms of Hydrogen for every atom.

REVIEW FOR TESTMACROMOLECULES. The four macromolecules are: Carbohydrates Proteins Lipids Nucleic acids.

1 Organic Chemistry Study of Compounds that contain Carbon. Study of Compounds that contain Carbon. Why is carbon so interesting? Why is carbon so interesting?

35.2 Defenses Against Infection

Chemical Compounds in Cells What are Elements and Compounds? What Compounds Do Cells Need?

Organic Chem Biochem Lab learnings Carbs Biochemistry.

THE STRUCTURE AND FUNCTION OF MACROMOLECULES Chapter 5.

Drug design and discovery New and old drugs. Secondary stage rash in syphylis on the palms of the hands. Bacteria Treponema pallidum Old drugs: treated.

Organic Compounds Hydrogen and other elements covalently bonded to carbon Four types of organic compounds: Carbohydrates Lipids Proteins Nucleic Acids.

Journal What sub atomic particle make up elements?  What are the charges? Name one compound What are 5 Properties of Water (there are 10 in total)

MACROMOLECULES EOC REVIEW Carbon serves as the backbone Carbon forms covalent bonds.

MACROMOLECULES.

2.3 Carbon-based Molecules

2.5 Carbohydrates.

19.6 Protein Hydrolysis and Denaturation

Proteins Proteins make up more than 50% of the dry weight of cells

Atoms are composed of: _______: negatively charged particles

Molecules of Life.

Unit 4.1 Day 2.

1 The Chemistry of Life.

Immunology & Public Health

Types of Weathering Tanner Fugal Savannah Chase Phil Corney TJ Moran

Macromolecules Overview

Carbohydrates Section 3.2.

Chapter 2: Macromolecules

Macromolecules/ AKA: Macronutrients

Chemical Compounds in Cells

Unit 4: Human Systems Chapter 1: Digestion

Proteins!!! More than just meat.

Chemical Compounds in Cells

Biochemistry Carbon Compounds.

Macromolecules Overview

Biochemistry Lysozyme – a protein.

Unit 4.1 Day 2.

Presentation transcript:

A.k.a : Muramidase OR N-acetylmuramide glycanhydrolase Lysozyme http://en.wikipedia.org/wiki/Lysozyme A.k.a : Muramidase OR N-acetylmuramide glycanhydrolase

Lysozyme An enzyme found naturally in • egg white • human tears • saliva (as well as other body fluids) Capable of destroying the cell walls of certain bacteria. Acts as a mild antiseptic.

Amino Sequence Fig 5. Lysozyme amino acid sequence alignment for five organisms (Dmelanogaste-fly, EcoligsnAA-E. coli, GgallusgsnAA-chicken, HsapiensgsnA-human, and Mmusculusgsn-mouse). Number to the left and right of the sequences and above each sequence group indicate amino acid number. Letters represent amino acids, with dashes (-) inserted to maximize sequence alignment. Black boxes indicate amino acid conservation.

Structure Made with 117 amino acid residues and has a heterogeneous sequence. 1REM 133L 1IWV Quaternary Structure (4°) <http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1rem#>

Function Lysozyme attacks peptidoglycans and hydrolyzes the glycosidic bond that connects N-acetylmuramic acid with the fourth carbon atom of N-acetylglucosamine. It does this by binding to the peptidoglycan molecule in the binding site within the prominent cleft between its two domains. Peptidoglycans- sugars & amino acids that form a mesh-like layer outside the plasma membrane of bacteria, forming the cell wall. Hydrolysis- Decomposition of a chemical compound by reaction with water, such as the dissociation of a dissolved salt or the catalytic conversion of starch to glucose. http://en.wikipedia.org/wiki/Lysozyme

Present in other Organisms • bacteriophages (viruses that infect bacteria) • bacteria • plants • animals

Misc… • Lysozyme was first identified and named by Alexander Fleming, who recognized its bacteriolytic properties. (1922) • Bottlefed babies are 3 times likely to have diarrheal disease, because they lack lysozyme in their diet... [its in breast milk!] Lysozyme is a natural form of protection from pathogens. Bacteriolysis -destruction or dissolution of bacterial cells

Works Cited: Yikrazuul. "Lysozyme." Wikipedia. N.p., 14 Oct. 2009. Web. 14 Oct. 2009. <http://en.wikipedia.org/ wiki/Lysozyme>. Muraki, M., et al. "HUMAN LYSOZYME WITH MAN-B1,4-GLCNAC COVALENTLY ATTACHED TO ASP53." RCSB Protein Data Bank. N.p., 14 Oct. 2009. Web. 14 Oct. 2009. <http://www.rcsb.org/pdb/cgi/ explore.cgi?pdbId=1rem>. 3. Secretlens. "Drool." DeviantArt. N.p., 15 July 2009. Web. 14 Oct. 2009. <http://secretlens.deviantart.com/art/Drool-129635147>. 4. funkipunk . “Tears Speak." DeviantArt. N.p., 13 Nov. 2007. Web. 14 Oct. 2009. <http://funkipunk.deviantart.com/art/Tears-Speak-69773894>. 5. Caothicart . “Dark Pikachu." DeviantArt. N.p., 10 June 2007. Web. 14 Oct. 2009. <http://caothicart.deviantart.com/art/Dark-Pikachu-57318376>. Chueh, Luke . “I ASKED FOR SCRAMBLED.” LukeChueh N.p., 2003. Web. 14 Oct. 2009. <http://www.lukechueh.com/paintings/i-asked-for-scrambled.html>. Stryer L. 1995. Biochemistry. 4th ed. New York: W.H. Freeman and Company. p 372. "MacDNAsis Analysis of Lysozyme Genbank search results." Davidson College. N.p., 30 Nov. 2001. Web. 14 Oct. 2009. <http://www.bio.davidson.edu/Courses/Molbio/MolStudents/01grnoland/ MacDNAsis.html>.